LNCaP model of human prostatic carcinoma

JS Horoszewicz, SS Leong, E Kawinski, JP Karr… - Cancer research, 1983 - AACR
… of a versatile new model suitable to study human prostatic cancer in the laboratory. … line
LNCaP and demon strates its utility as a model for laboratory studies on human prostatic cancer

LNCaP progression model of human prostate cancer: Androgen‐independence and osseous metastasis

GN Thalmann, RA Sikes, TT Wu, A Degeorges… - … Prostate, 2000 - Wiley Online Library
… By means of constructing a cell-cell recombination model [3,4], … LNCaP prostate cancer
model. A series of lineage-related LNCaP cell sublines that reflect the various steps of prostate

Establishment and characterization of androgen‐independent human prostate cancer LNCaP cell model

T Igawa, FF Lin, MS Lee, D Karan, SK Batra… - The Prostate, 2002 - Wiley Online Library
… hormone-refractory prostate cancer. To investigate … prostate cancer, we established a useful
LNCaP cell model that resembles the clinical scenario of hormone-refractory prostate cancer

Model systems of prostate cancer: uses and limitations

NM Navone, CJ Logothetis… - Cancer and metastasis …, 1998 - Springer
… the properties of the prostate cancer model systems in use and … This review will guide the
investigator seeking models with … , LNCaP has been used widely as a model for prostate cancer

Androgen-independent cancer progression and bone metastasis in the LNCaP model of human prostate cancer

GN Thalmann, PE Anezinis, SM Chang, HE Zhau… - Cancer research, 1994 - AACR
… parental LNCaP cells. This experimental human prostate cancer model may permit, for the
… time, the study of the molecular mechanisms underlying human prostate cancer metastasis. …

In Vivo Progression of LAPC-9 and LNCaP Prostate Cancer Models to Androgen Independence Is Associated with Increased Expression of Insulin-like Growth Factor I (IGF-I) …

T Nickerson, F Chang, D Lorimer, SP Smeekens… - Cancer research, 2001 - AACR
… availability of suitable models. The work we report here is based on three human prostate
cancer models of in vivo progression to androgen independence, LAPC-9, LNCaP, and LAPC-…

A metastatic and androgen-sensitive human prostate cancer model using intraprostatic inoculation of LNCaP cells in SCID mice

N Sato, ME Gleave, N Bruchovsky, PS Rennie… - Cancer research, 1997 - AACR
prostate cancer model with differentiated features using the human LNCaP cell line.
Athymic and SCID mice were injected either sc or intraprostatically with 1 x 106 LNCaP cells. …

Development of human prostate cancer models for chemoprevention and experimental therapeutics studies

LWK Chung, HE Zhau, TT Wu - Journal of Cellular Biochemistry, 1997 - Wiley Online Library
… human prostate cancer models to study the molecular events leading to prostate cancer
To complement the LNCaP model, we have recently developed another highly metastatic …

Multiple metastases in a novel LNCaP model of human prostate cancer

M Zou, J Jiao, Q Zou, Y Xu, M Cheng… - Oncology …, 2013 - spandidos-publications.com
… strategies; however, few models exist at present. In the present study, the LNCaP
prostate cancer cell line was co-transfected with a PGK-luciferase-GFP lentivirual vector (LNCaP-luc). …

The human prostatic cancer cell line LNCaP and its derived sublines: an in vitro model for the study of androgen sensitivity

GJ van Steenbrugge, CJC Van Uffelen, J Bolt… - The Journal of steroid …, 1991 - Elsevier
… of suitable model systems. Among the small number of permanent in vitro cell lines of human
prostate cancer described up to now, the LNCaP (lymphe node carcinoma of the prostate) …