… of classic lobular neoplasia and pleomorphic lobular … for patients with classic lobular
neoplasia and eradication of the … an association between classic types and increased bilateral …

… Calcifications and comedo-type necrosis can often be observed (B, C). The … Classic invasive
lobular lesions are low-grade ER-positive breast cancers, characterized by recurrent losses …

… In summary, the cells of classic LCIS … type A cells, have small nuclei with dense and indistinct
chromatin, no nucleoli, and inconspicuous cytoplasm; the large cells, or Haagensen’s type …

… times the size of a lymphocyte (type A) and those with more … classic and pleomorphic LN.
In fact, recent molecular profiling studies comparing invasive classic and pleomorphic lobular …

… risk of developing carcinoma: pleomorphic LCIS > Classic LCIS > DIALH > ALH. The term
"indeterminate in situ lesions" (IILs) or "mixed type lesions" was used to describe certain breast …

… overlapping developmental pathway for these lobular tumor types. Molecular alterations found
… carcinoma in situ were associated with calcifications: the classic form with small, uniform …

… Pathology May include type A or type B epithelial cells. Typically pale or eosinophilic Nuclei
are at … Classical LN typically has phenotypical characteristics consistent with the luminal A …

… The defining pathological features shared by classical examples of lobular lesions are …
central comedo-type necrosis with calcification. This type of in situ lobular neoplasia can be …

… nuclei and scant cytoplasm (referred to as ‘type A’ cells 2 ), in some cases the … type B’ cells)
(Figure 4). Lesions composed of either cell types are referred to as ‘classic’ lobular neoplasia …

… carcinoma in situ was further categorized into classic type, pleomorphic type, or lobular
carcinoma in situ with necrosis. Several cases in our study had an original diagnosis of ‘mixed …