… combating local infections yet can induce organ injury during systemic infection. … locally
beneficial host defense mechanisms can become detrimental when activated systemically. Local …

… Experimental models of acute pancreatitis and remote organ injury … of acute pancreatitis
and remote organ injury. By using these … and remote organ injury has been identified [109]. …

… Natural antibodies, the alternative complement pathway, and local inflammation are … local
defenses by preventing both microbial dissemination and self-inflicted injury to distant organs…

… local hypoxia that develops following injury (8–12). They also produce soluble mediators such
as TGF-β1 that stimulate local … defense in the lung, they can also contribute to tissue injury…

… without other extrapulmonic organ injury is a localized … generalized endothelial injury in
multiple organs. Accordingly, … Consequently, increased local tissue oxygen demand may …

… of local lung tissue revealed no differences in acute lung injury … severe damage and necrosis
to multiple organs (liver, spleen, … in protecting the organs from systemic injury caused by a …

… HS and quantification of organ injury and dysfunction were … , which makes these organs
less resistant to organ injury. In … Akt-survival pathway reduces organ injury in many conditions …

… the changes of multiple system organ failure (MSOF) and gut … group developed multiple
system organ injuries or failures … The pathological results support the gut barrier function injury…

… end-organ injury after peripheral tissue injury, we … injury stimulates a local inflammatory
response but also sets in motion a systemic inflammatory cascade leading to remote organ injury …

… to investigate the complement activation in multiply injured pigs as well as its … injured pigs
showed complement activation in serum within 6 h after trauma, we next investigated the local …