Resistance to loop diuretics: why it happens and what to do about it

DC Brater - Drugs, 1985 - Springer
… In summary, resistance to loop diuretics in patients with nephrotic syndrome and relatively
normal renal function is pharmacodynamic in nature. The mechanism of this interaction may …

Diuretic resistance

EJ Hoorn, DH Ellison - American Journal of Kidney Diseases, 2017 - Elsevier
… , the potential pharmacokinetic causes of diuretic resistance should be … diuretic or by
admitting patients for intravenous loop diuretic treatment (as in our case). The type of loop diuretic

Loop diuretic resistance in heart failure: resistance etiology–based strategies to restoring diuretic efficacy

ZL Cox, DJ Lenihan - Journal of cardiac failure, 2014 - Elsevier
… In case 5, we encounter diuretic resistance to high-dose loop diuretics and sequential
nephron blockade in the setting of CRS and elevated IAP. Further increases in diuretic doses are …

Management of loop diuretic resistance in the intensive care unit

K Asare - American Journal of Health-System Pharmacy, 2009 - academic.oup.com
… Prolonged use of loop diuretics may lead to loop diuretic resistance, a frequent observation
… to explain loop diuretic resistance: rebound sodium retention, postdiuretic effect, and diuretic

Diuretic strategies for loop diuretic resistance in acute heart failure: the 3T trial

ZL Cox, R Hung, DJ Lenihan, JM Testani - Heart Failure, 2020 - jacc.org
loop diuretic therapy during DR in AHF are needed. This study investigated the efficacy and
safety of diuretic combination strategies using high-dose loop diuretic … -dose loop diuretics. …

Loop diuretics, renal function and clinical outcome in patients with heart failure and reduced ejection fraction

K Damman, J Kjekshus, J Wikstrand… - European journal of …, 2016 - Wiley Online Library
… the use of loop diuretics, higher loop diuretic dose, and risk of … use of a loop diuretic and the
dose of loop diuretic taken were … , diuretic resistance develops, requiring higher dosages of …

Loop diuretic resistance complicating acute heart failure

ZL Cox, JM Testani - Heart Failure Reviews, 2020 - Springer
… the patient with AHF and diuretic resistance based upon the relative incidence of diuretic
resistance mechanisms and the current literature supporting efficacy and safety of the diuretic

[HTML][HTML] Diuretic strategies in patients with resistance to loop-diuretics in the intensive care unit: A retrospective study from the MIMIC-III database

JM Cote, J Bouchard, PT Murray… - Journal of Critical …, 2021 - Elsevier
… various diuretic strategies to alleviate loop-diuretics resistance in critically ill patients. …
strategies were investigated: incremental dose of loop diuretics, continuous infusion, combinations …

Responsiveness to loop diuretics in heart failure

E Braunwald - European Heart Journal, 2014 - academic.oup.com
… I think that it is likely that diuretic resistance is both a marker and a ‘player’. Whatever the …
development of loop diuretic resistance is an ominous prognostic sign in patients with HF. …

Renal tubular resistance is the primary driver for loop diuretic resistance in acute heart failure

JM Ter Maaten, VS Rao, JS Hanberg… - European journal of …, 2017 - Wiley Online Library
resistance being impaired delivery of diuretic to the tubule (ie … , such as continuous loop
diuretic infusions, have yielded … to be a predominant driver of diuretic resistance in AHF.10, 22 …