Low-abundance drug-resistant viral variants in chronically HIV-infected, antiretroviral treatment–naive patients significantly impact treatment outcomes

BB Simen, JF Simons, KH Hullsiek… - The Journal of …, 2009 - academic.oup.com
… nearly doubled when low-abundance resistant variants identified … our results, suggest that
low-abundance drug-resistant HIV … , and that these low-abundance drug-resistant variants may …

Low-abundance HIV drug-resistant viral variants in treatment-experienced persons correlate with historical antiretroviral use

T Le, J Chiarella, BB Simen, B Hanczaruk, M Egholm… - PloS one, 2009 - journals.plos.org
Antiretroviral treatment histories were obtained by chart review and correlated with drug-resistant
mutations. Low-abundance … The additional low-abundance drug-resistant mutations …

Impact of pretreatment low-abundance HIV-1 drug resistance on virological failure after 1 year of antiretroviral therapy in China

M Li, C Song, J Hu, A Dong, R Kang… - Journal of …, 2023 - academic.oup.com
… In addition, the analysis of different cut-offs of virological failure was conducted in this study,
and it was found that low-abundance PDR still had certain impact on treatment efficacy in …

Low-abundance drug-resistant HIV-1 variants in antiretroviral drug-naive individuals: a systematic review of detection methods, prevalence, and clinical impact

HA Mbunkah, S Bertagnolio, RL Hamers… - The Journal of …, 2020 - academic.oup.com
… on HIV-1 drug resistance testing by the International Antiviral Society USA [116]. Although
just a single study in this review reported low-abundance INSTI-DRVs at a prevalence of 2.4% …

High prevalence of HIV low abundance drug-resistant variants in a treatment-naive population in North Rift Kenya

W Cheriro, M Kiptoo, G Kikuvi, S Mining… - AIDS research and …, 2015 - liebertpub.com
antiretroviral treatment (ART) has resulted in a dramatic reduction in AIDS-related morbidity
and mortality. However, the emergence and spread of antiretrovirallow abundance drug-…

Low-abundance drug-resistant HIV-1 variants: finding significance in an era of abundant diagnostic and therapeutic options

RW Shafer - The Journal of infectious diseases, 2009 - academic.oup.com
… , the presence of low-abundance DRMs before a change in … not contain antiretroviral drugs
to which the low-abundance … of low-abundance nevirapine-resistant variants when treated

Impact of low abundance HIV variants on response to ritonavir-boosted atazanavir or fosamprenavir given once daily with tenofovir/emtricitabine in antiretroviral-naive …

LL Ross, WG Weinberg, E DeJesus… - AIDS research and …, 2010 - liebertpub.com
… of antiretroviral treatment failure. Population genotyping (PG) of HIV is routinely used to help
guide treatment of HIV-… in the detection of low abundance HIV variants containing resistance …

Low-abundance resistant mutations in HIV-1 subtype C antiretroviral therapy-naive individuals as revealed by pyrosequencing

S Gonzalez, DC Tully, C Gondwe… - Current HIV …, 2013 - ingentaconnect.com
… of lowabundance drug-resistant variants that exist in treatment… -experienced persons
correlate with historical antiretroviral … Dynamics of HIV-1 quasispecies during antiviral treatment

Low-frequency drug resistance in HIV-infected Ugandans on antiretroviral treatment is associated with regimen failure

F Kyeyune, RM Gibson, I Nankya… - Antimicrobial agents …, 2016 - Am Soc Microbiol
low-frequency HIV drug resistance mutations by deep sequencing in Ugandan patients failing
antiretroviral treatment … We showed that these low-abundance drug-resistant viruses could …

Low-abundance drug resistance mutations: extending the HIV paradigm to hepatitis B virus

S Menzo, D Vincenti, M Solmone… - The Journal of …, 2009 - academic.oup.com
… In conclusion, HBV, similarly to HIV, replicates in quasispecies with several low-abundance
variants, including mutations in drug resistance key residues. Whether traces of archived …