… of cataract induction in isolated lens epithelial cells (LEC) exposed to ionizing … doses of 137
Cs gamma rays (0, 0.1, 0.25 and 0.5 Gy), at low (0.065 Gy/min) and higher (0.3 Gy/min) dose …

… The HLE-B3 human lens epithelial cell line (ATCC) was seeded in EMEM medium … The
HLE-B3 cell line used in this study is an immortalized human lens epithelial cell line generated …

… of the lens, are likely to be involved. Materials and Methods: In this work, the lens epithelium
has … The responses of epithelial cells located at the anterior pole (central region) have been …

… level of glutathione is likely to be higher at low doses and decreases at high doses relative
to the control, in both the nucleus and cytoplasm. At the high doses, there may be a shift in the …

… lens epithelium as the initiation site for cataract development, it seemed timely to review recent
studies which appear to establish UV damage in the lens epithelium … relatively low doses …

… the differentiating lens epithelium rather than earlier stages, prior to lens vesicle formation.
There are several excellent recent reviews of the roles these genes in lens induction and …

… Indeed, one of the largest cohort studies of radiology technologists in the US reported an
excess risk of cataract from low dose (<100 mGy cumulative lens exposure) and low-…

… Further exploration of the relation of DNA damage responses and RIBE at low dose rate is …
likely that a cell cycle phase transition during low-dose-rate exposure resulted in higher levels …

… of lens cells. Our previous work was the first to evaluate the radiosensitivity of lens cells with
the clonogenic assay, documenting that the survival of HLEC1 human lens epithelial cells is …

… Low doses of dexamethasone cause a moderate increase in proliferation of cultured HLECs.
Slightly higher but still physiologically relevant concentrations of dexamethasone result in …