Early responses to low-dose ionizing radiation in cellular lens epithelial models
M Ahmadi, S Barnard, E Ainsbury… - Radiation …, 2022 - meridian.allenpress.com
… of cataract induction in isolated lens epithelial cells (LEC) exposed to ionizing … doses of 137
Cs gamma rays (0, 0.1, 0.25 and 0.5 Gy), at low (0.065 Gy/min) and higher (0.3 Gy/min) dose …
Cs gamma rays (0, 0.1, 0.25 and 0.5 Gy), at low (0.065 Gy/min) and higher (0.3 Gy/min) dose …
Low-dose ionizing radiation: Effects on the proliferation and migration of lens epithelial cells via activation of the Wnt/β-catenin pathway
P Wang, YW Li, X Lu, Y Liu, XL Tian, L Gao… - … /Genetic Toxicology and …, 2023 - Elsevier
… The HLE-B3 human lens epithelial cell line (ATCC) was seeded in EMEM medium … The
HLE-B3 cell line used in this study is an immortalized human lens epithelial cell line generated …
HLE-B3 cell line used in this study is an immortalized human lens epithelial cell line generated …
Dotting the eyes: mouse strain dependency of the lens epithelium to low dose radiation-induced DNA damage
SGR Barnard, J Moquet, S Lloyd… - … Journal of Radiation …, 2018 - Taylor & Francis
… of the lens, are likely to be involved. Materials and Methods: In this work, the lens epithelium
has … The responses of epithelial cells located at the anterior pole (central region) have been …
has … The responses of epithelial cells located at the anterior pole (central region) have been …
Raman micro-spectroscopy analysis of human lens epithelial cells exposed to a low-dose-range of ionizing radiation
… level of glutathione is likely to be higher at low doses and decreases at high doses relative
to the control, in both the nucleus and cytoplasm. At the high doses, there may be a shift in the …
to the control, in both the nucleus and cytoplasm. At the high doses, there may be a shift in the …
The role of the lens epithelium in development of UV cataract
KR Hightower - Current eye research, 1995 - Taylor & Francis
… lens epithelium as the initiation site for cataract development, it seemed timely to review recent
studies which appear to establish UV damage in the lens epithelium … relatively low doses …
studies which appear to establish UV damage in the lens epithelium … relatively low doses …
The lens epithelium in ocular health and disease
G Martinez, RU De Iongh - The international journal of biochemistry & cell …, 2010 - Elsevier
… the differentiating lens epithelium rather than earlier stages, prior to lens vesicle formation.
There are several excellent recent reviews of the roles these genes in lens induction and …
There are several excellent recent reviews of the roles these genes in lens induction and …
Lens epithelial cell proliferation in response to ionizing radiation
… Indeed, one of the largest cohort studies of radiology technologists in the US reported an
excess risk of cataract from low dose (<100 mGy cumulative lens exposure) and low-…
excess risk of cataract from low dose (<100 mGy cumulative lens exposure) and low-…
[HTML][HTML] The impact of dose rate on responses of human lens epithelial cells to ionizing irradiation
… Further exploration of the relation of DNA damage responses and RIBE at low dose rate is …
likely that a cell cycle phase transition during low-dose-rate exposure resulted in higher levels …
likely that a cell cycle phase transition during low-dose-rate exposure resulted in higher levels …
[HTML][HTML] Ionizing radiation response of primary normal human lens epithelial cells
N Hamada - PLoS One, 2017 - journals.plos.org
… of lens cells. Our previous work was the first to evaluate the radiosensitivity of lens cells with
the clonogenic assay, documenting that the survival of HLEC1 human lens epithelial cells is …
the clonogenic assay, documenting that the survival of HLEC1 human lens epithelial cells is …
[HTML][HTML] Effects of dexamethasone on human lens epithelial cells in culture
A Petersen, T Carlsson, JO Karlsson, S Jonhede… - Molecular …, 2008 - ncbi.nlm.nih.gov
… Low doses of dexamethasone cause a moderate increase in proliferation of cultured HLECs.
Slightly higher but still physiologically relevant concentrations of dexamethasone result in …
Slightly higher but still physiologically relevant concentrations of dexamethasone result in …
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