… ultrafine mapping of the LPA gene region involving 2426 variants genotyped within a 660-kb …
To select variants for inclusion in the genetic score, we identified variants in the LPA gene …

… We analyzed data from 4 clinical trials of the ASO … patients randomized to Lp(a) lowering
trials, LPA genetic variants are common, but a sizable proportion do not carry common variants …

… is located in the potentially functional region preceding the splice site acceptor and preliminary
analyses in those 43 carriers had indicated an effect on Lp(a) (12). In the present study …

… of the LPA gene and was the first to conduct a Mendelian randomization study on lipoprotein…
Genetic variants of interest in the LPA gene region.This table summarizes information about …

… The HPS investigated the association of this variant with vascular risk response to … this
variant. However, none of these studies provided a direct estimate of the risk conferred by the LPA …

… Our primary analysis was a meta-analysis of cases and controls identified at 4 eMERGE sites…
Notably, a mendelian randomization study of LPA variants associated with both Lp(a) levels …

… We conducted observational and genetic instrumental variable analyses in a Mendelian
randomization study design, assessing evidence of causality, and we performed mediation …

… Indeed, our observations highlight the need of scaling such analyses up to locus- or
genome-wide approaches. Unfortunately, since 4925G>A is located in the KIV-2 repeat, only the …

… , Lp(a) levels, and AS, mendelian randomization studies suggest that elevated Lp(a) … LPA
variants and AS. Fourth, as is frequently performed for large-scale genetic studies, our analysis …

… between subjects were analyzed with analysis of variance … analysis was used to estimate
the associations between LPA … Lipoprotein(a) genetic variants associated with coronary and …