ALKrearrangement in non‐small‐cell lung cancer (NSCLC)

X Du, Y Shao, HF Qin, YH Tai, HJ Gao - Thoracic cancer, 2018 - Wiley Online Library
… Subsequently, ALK-rearrangement (ALK-R… lung cancer (NSCLC), and esophageal squamous
cell, colorectal, and breast carcinomas.6, 7 ALK rearrangements create an oncogenic ALK

Unique Clinicopathologic Features Characterize ALK-Rearranged Lung Adenocarcinoma in the Western Population

SJ Rodig, M Mino-Kenudson, S Dacic, BY Yeap… - Clinical cancer …, 2009 - AACR
… of lung adenocarcinomas derived from the Asian populations harbor anaplastic large cell
kinase gene (ALK) gene rearrangements… that lung adenocarcinomas with ALK rearrangements

[HTML][HTML] Overview of clinicopathologic features of ALK-rearranged lung adenocarcinoma and current diagnostic testing for ALK rearrangement

H Kim, JH Chung - Translational Lung Cancer Research, 2015 - ncbi.nlm.nih.gov
ALK inhibitor treatment. However, lung cancer patients with ALK gene rearrangement
after ALK … In this review, the authors summarize the clinicopathologic features of ALK-rearranged

[HTML][HTML] Histologic and cytomorphologic features of ALK-rearranged lung adenocarcinomas

M Nishino, VE Klepeis, BY Yeap, K Bergethon… - Modern Pathology, 2012 - Elsevier
… system for predicting ALK rearrangements in lung adenocarcinomas. The scoring system …
ALK rearrangements in a new cohort of 78 lung adenocarcinomas (29 ALK+ and 49 ALK−) with …

Clinical characteristics associated with ALK rearrangements in never-smokers with pulmonary adenocarcinoma

JM Sun, M Lira, K Pandya, YL Choi, JS Ahn, M Mao… - Lung cancer, 2014 - Elsevier
ALK rearrangements was high in the clinically enriched population of never-smokers with
pulmonary adenocarcinoma. … status in this population, the ALK-positive rate can be anticipated …

[HTML][HTML] Patterns of DNA mutations and ALK rearrangement in resected node negative lung adenocarcinoma

PY Yip, B Yu, WA Cooper, CI Selinger, CC Ng… - Journal of Thoracic …, 2013 - Elsevier
… Interphase fluorescence in situ hybridisation for ALK rearrangement was performed on … for
ALK rearrangement using the Vysis LSI ALK Dual Color, Break Apart Rearrangement Probe (…

ALK rearrangement in specific subtypes of lung adenocarcinoma: immunophenotypic and morphological features

L Possidente, M Landriscina, G Patitucci, L Borgia… - Medical oncology, 2017 - Springer
… The analysis of our series of 94 lung adenocarcinomas … IHC for ALK fusion protein and
presence of ALK rearrangement … of ALK rearrangement in TTF1-positive lung adenocarcinomas. …

[HTML][HTML] ALK gene rearrangements: a new therapeutic target in a molecularly defined subset of non-small cell lung cancer

B Solomon, M Varella-Garcia, DR Camidge - Journal of thoracic oncology, 2009 - Elsevier
… cancers, they are more frequent in adenocarcinomas, in never or light smokers… ALK
rearrangements treated on a phase I study with PF02341066, an oral ALK inhibitor, indicate that ALK

[HTML][HTML] Clinical outcomes in ALK-rearranged lung adenocarcinomas according to ALK fusion variants

YJ Cha, HR Kim, HS Shim - Journal of translational medicine, 2016 - Springer
… A retrospective analysis was conducted on patients with advanced ALK-rearranged
adenocarcinoma treated with chemotherapy and ALK inhibitors. ALK rearrangement was identified …

[HTML][HTML] ALK-rearrangements and testing methods in non-small cell lung cancer: a review

RE Shackelford, M Vora, K Mayhall… - Genes & cancer, 2014 - ncbi.nlm.nih.gov
… Peled et al. [121] used comprehensive genomic profiling by second generation sequencing
… a complex ALK rearrangement in a lung adenocarcinoma previously found to be EML4-ALK