… and treatment outcomes of patients with lung adenocarcinomas with ROS1 rearrangement.
… We screened ROS1 rearrangements in 208 never smokers with lung adenocarcinoma. …

… ROS1 rearrangement is commonly mutually exclusive with other alterations involving
driver … in lung cancer. According to this view, a recent study on 62 patients with ROS1-rearranged …

… of lung adenocarcinomas (ACAs) and are associated with response to the multitargeted
tyrosine kinase inhibitor crizotinib. ROS1 rearrangements … (IHC) for ROS1 protein is a promising …

… , 121 triple negative lung adenocarcinomas were screened by both IHC with the ROS1
D4D6 … expression of the ROS1 protein in ROS1-rearranged lung adenocarcinomas. Non-specific …

… ROS1 is normally expressed in the lung and other organs, although its physiological function
remains unclear. ROS1 rearrangement … In lung cancer, several ROS1 fusion partners have …

… study in centers that tested for ROS1 rearrangement. Eligible patients had stage IV lung
adenocarcinoma, had ROS1 rearrangement according to fluorescent in situ hybridization, and …

… These efforts have led to the discovery of novel oncogenic fusion gene such as ROS1 and
RET. ROS1 rearrangements in lung cancer were first identified in the non-small cell cancer …

… The first report of ROS1 rearrangements in lung cancer dates back to 2007. ROS1 fusions
have … ROS1 rearrangement in the HCC78 cell line was found to be associated with in vitro …

… of ROS1 rearrangements in lung adenocarcinomas. We also showed that IHC is a sensitive
tool, but that non-rearranged … FISH is necessary, especially in ROS1-expressed tumors. …

… exclusively in adenocarcinomas, which is … ROS1 screening in adenocarcinoma patients
with no known oncogenic aberrations is an effective strategy to find ROS1 rearrangements …