… The very broad range of tyrosine kinase target mutations seen in ALK-rearranged lung cancer
with acquired resistance to crizotinib is reminiscent of the variety of resistance mutations to …

… We consider the multifaceted resistance mechanisms tumors utilize, often simultaneously. …
acquired resistance, as it remains the major scientific and clinical challenge in lung cancer. …

… Several possible mechanisms for acquired resistance have been … of acquired TKI resistance
in EGFR-mutant lung cancer and review … Clin Cancer Res; 17(17); 5530–7. ©2011 AACR. …

… , acquired resistance is ubiquitous and remains a key challenge. Investigations into the
mechanisms which foster resistance … -small cell lung cancer patients with acquired resistance to …

… or acquisition of a PIK3CA mutation has not been identified as a mechanism of resistance
in lung cancer … and preclinical studies suggest that if a cancer can find a way to effectively …

… in classification of acquired resistance that require urgent … lung cancer treatment with
unprecedented durability of responses in patients with advanced disease, but acquired resistance (…

… acquire resistance to either drug. Currently, the clinical definition of such secondary or
acquired resistance … be used to define more precisely acquired resistance to EGFR TKIs. All …

… Diversity and ductility in acquiring resistance to TKIs in EGFR-mutated lung cancers. HCC827
lung cancer cells, shown here, are frequently used as in vitro acquired resistance models; …

… lung cancer develop disease progression after a median of 10 to 14 months on EGFR TKI.
Different mechanisms of acquired resistance to … mechanisms of acquired resistance is not yet …

… Here, we summarized the impact of immunotherapy on lung cancer … and acquired resistance
to immunotherapy in this disease. … in lung cancer, with a focus on the underlying resistance …