Acquired resistance to TKIs in solid tumours: learning from lung cancer
… The very broad range of tyrosine kinase target mutations seen in ALK-rearranged lung cancer
with acquired resistance to crizotinib is reminiscent of the variety of resistance mutations to …
with acquired resistance to crizotinib is reminiscent of the variety of resistance mutations to …
[HTML][HTML] Acquired resistance in lung cancer
A Tulpule, TG Bivona - Annual Review of Cancer Biology, 2020 - annualreviews.org
… We consider the multifaceted resistance mechanisms tumors utilize, often simultaneously. …
acquired resistance, as it remains the major scientific and clinical challenge in lung cancer. …
acquired resistance, as it remains the major scientific and clinical challenge in lung cancer. …
New strategies in overcoming acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in lung cancer
… Several possible mechanisms for acquired resistance have been … of acquired TKI resistance
in EGFR-mutant lung cancer and review … Clin Cancer Res; 17(17); 5530–7. ©2011 AACR. …
in EGFR-mutant lung cancer and review … Clin Cancer Res; 17(17); 5530–7. ©2011 AACR. …
Acquired resistance to EGFR targeted therapy in non-small cell lung cancer: Mechanisms and therapeutic strategies
SM Lim, NL Syn, BC Cho, RA Soo - Cancer treatment reviews, 2018 - Elsevier
… , acquired resistance is ubiquitous and remains a key challenge. Investigations into the
mechanisms which foster resistance … -small cell lung cancer patients with acquired resistance to …
mechanisms which foster resistance … -small cell lung cancer patients with acquired resistance to …
Mechanisms of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non–small cell lung cancer
JA Engelman, PA Jänne - Clinical Cancer Research, 2008 - AACR
… or acquisition of a PIK3CA mutation has not been identified as a mechanism of resistance
in lung cancer … and preclinical studies suggest that if a cancer can find a way to effectively …
in lung cancer … and preclinical studies suggest that if a cancer can find a way to effectively …
[HTML][HTML] Clinical definition of acquired resistance to immunotherapy in patients with metastatic non-small-cell lung cancer
… in classification of acquired resistance that require urgent … lung cancer treatment with
unprecedented durability of responses in patients with advanced disease, but acquired resistance (…
unprecedented durability of responses in patients with advanced disease, but acquired resistance (…
Clinical definition of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non–small-cell lung cancer
… acquire resistance to either drug. Currently, the clinical definition of such secondary or
acquired resistance … be used to define more precisely acquired resistance to EGFR TKIs. All …
acquired resistance … be used to define more precisely acquired resistance to EGFR TKIs. All …
Acquired resistance mechanisms to tyrosine kinase inhibitors in lung cancer with activating epidermal growth factor receptor mutation—diversity, ductility, and destiny
K Suda, H Mizuuchi, Y Maehara… - Cancer and Metastasis …, 2012 - Springer
… Diversity and ductility in acquiring resistance to TKIs in EGFR-mutated lung cancers. HCC827
lung cancer cells, shown here, are frequently used as in vitro acquired resistance models; …
lung cancer cells, shown here, are frequently used as in vitro acquired resistance models; …
[HTML][HTML] Management of acquired resistance to EGFR TKI–targeted therapy in advanced non-small cell lung cancer
SG Wu, JY Shih - Molecular cancer, 2018 - Springer
… lung cancer develop disease progression after a median of 10 to 14 months on EGFR TKI.
Different mechanisms of acquired resistance to … mechanisms of acquired resistance is not yet …
Different mechanisms of acquired resistance to … mechanisms of acquired resistance is not yet …
[HTML][HTML] Primary and acquired resistance to immunotherapy in lung cancer: unveiling the mechanisms underlying of immune checkpoint blockade therapy
L Boyero, A Sánchez-Gastaldo, M Alonso… - Cancers, 2020 - mdpi.com
… Here, we summarized the impact of immunotherapy on lung cancer … and acquired resistance
to immunotherapy in this disease. … in lung cancer, with a focus on the underlying resistance …
to immunotherapy in this disease. … in lung cancer, with a focus on the underlying resistance …
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