… or locally advanced non-small cell lung cancer (NSCLC). A number of studies over the last
two decades have focussed on dose escalation as a means of improving disease control and …

… volumes are below the excess reserve capacity of lung and the mean lung dose remains
below 20 Gy (20). This is the basis of a “standard” dose escalation program, but we show that it …

… Finally, dose escalation with conventional fractionation and concurrent … dose escalation
with altered fractionation, individualised radiation dose escalation based on normal tissue dose …

… control with dose escalation. Kong et al. published a phase I study of dose escalation at the
University of Michigan, treating with doses up to 103 Gy based on effective lung volume, with …

… Boost dose levels were escalated up to predefined normal tissue constraints … lung dose
in both arms. This also forces an equal mean PTV dose in both arms, hence testing pure dose-…

… dose regardless of the volume of normal lung irradiated, we opted to develop a dose escalation
schema in which the dose … In creating the escalation schema, the decision was first made …

… In this study, IMRT was shown to reduce the mean lung dose; furthermore, adaptive IMRT …
in dose escalation for larger GTVs, and was able to achieve maximal iso-toxic dose escalation …

… to treatment of unresectable stage III lung cancer, and we outline the early and the more
recent dose escalation studies. While dose escalation appears to provide a modest benefit in …

… A recent study has shown, by comparing lung cancer … technique, that substantial dose
escalation is possible at constant … non-small cell lung cancer, it was found that dose escalation in …

… Several institutions have reported results of dose escalation … feature in the design of these
dose escalation trials is the use of … dose–volume parameters for lung such as the mean lung …