Epidermal growth factor receptor mutations in lung cancer

SV Sharma, DW Bell, J Settleman, DA Haber - Nature Reviews Cancer, 2007 - nature.com
… that target the epidermal growth factor receptor (EGFR) provide important insights for new
lung cancer therapies, as well as for the broader field of targeted cancer therapies. We review …

Epidermal growth factor receptor family in lung cancer and premalignancy

WA Franklin, R Veve, FR Hirsch, BA Helfrich… - Seminars in …, 2002 - Elsevier
… proteins, particularly overexpression of epidermal growth factor receptor (EGFR) family …
EGF and transforming growth factor alpha. Epidermal growth factor receptor overexpression is …

The biology of epidermal growth factor receptor in lung cancer

GV Scagliotti, G Selvaggi, S Novello, FR Hirsch - Clinical Cancer Research, 2004 - AACR
The prognostic significance of epidermal growth factor receptor (EGFR) expression in lung
cancer and, more importantly, its ability to predict response to anti-EGFR therapies, are …

Epidermal growth factor receptors in non-small cell lung cancer

D Veale, T Ashcroft, C Marsh, GJ Gibson… - … journal of cancer, 1987 - nature.com
… Our results suggest thatepidermal growth factor receptor may play a part in the genesis or
spread of lung cancers. This is the third common primary carcinoma in which we have found a …

Mutations of the Epidermal Growth Factor Receptor Gene in Lung Cancer: Biological and Clinical Implications

T Kosaka, Y Yatabe, H Endoh, H Kuwano, T Takahashi… - Cancer research, 2004 - AACR
… epidermal growth factor receptor(EGFR) gene occur in a subset of patients with lung cancer
… To gain further insights in the role of EGFR in lung carcinogenesis, we sequenced exons 18…

[HTML][HTML] Screening for epidermal growth factor receptor mutations in lung cancer

R Rosell, T Moran, C Queralt, R Porta… - … England Journal of …, 2009 - Mass Medical Soc
growth factor receptor (EGFR), PI3K, BRAF, and K-ras genes are generally nonoverlapping
and identifiable in approximately 40% of non–small-cell lung cancers… small-cell lung cancers. …

[HTML][HTML] Epidermal growth factor receptor (EGFR) in lung cancer: an overview and update

G Bethune, D Bethune, N Ridgway… - Journal of thoracic …, 2010 - ncbi.nlm.nih.gov
… Mutations in epidermal growth factor receptor have been discovered in association with
some lung cancers. Lung adenocarcinomas with mutated epidermal growth

The Fibroblast Growth Factor Receptor Inhibitor PD173074 Blocks Small Cell Lung Cancer Growth In vitro and In vivo

OE Pardo, J Latigo, RE Jeffery, E Nye, R Poulsom… - Cancer research, 2009 - AACR
… Our previous work showed that fibroblast growth factor-2 induces … growth factor receptor
(FGFR) inhibitor PD173074 blocks H-510 and H-69 SCLC proliferation and clonogenic growth in …

[HTML][HTML] Epidermal growth factor receptor inhibition in lung cancer: status 2012

FR Hirsch, PA Jänne, WE Eberhardt… - Journal of Thoracic …, 2013 - Elsevier
Lung cancer is the most common cause of cancer deaths. … However, with the understanding
of lung cancer biology, and … patients with non–small-cell lung cancer (NSCLC). Epidermal …

Epidermal growth factor family of receptors in preneoplasia and lung cancer: perspectives for targeted therapies

FR Hirsch, GV Scagliotti, CJ Langer, M Varella-Garcia… - Lung cancer, 2003 - Elsevier
… in patients with lung cancer [4], [5… lung cancer. The gene mechanisms for the protein
expression will be discussed, and for the HER2, differences between lung cancer and breast cancer