Nuclear EGFR as a molecular target in cancer
TM Brand, M Iida, N Luthar, MM Starr… - Radiotherapy and …, 2013 - Elsevier
… functions have been inversely correlated with overall patient survival in breast, ovarian,
oropharyngeal, gallbladder, and lung cancer providing a strong rationale for the molecular …
oropharyngeal, gallbladder, and lung cancer providing a strong rationale for the molecular …
Nuclear EGFR protein expression predicts poor survival in early stage non-small cell lung cancer
AM Traynor, TL Weigel, KR Oettel, DT Yang, C Zhang… - Lung cancer, 2013 - Elsevier
… Nuclear EGFR protein expression was associated with higher disease stage (45.5% of stage
II vs. … Nuclear EGFR serves as a useful independent prognostic variable and as a potential …
II vs. … Nuclear EGFR serves as a useful independent prognostic variable and as a potential …
[HTML][HTML] Nuclear mode of the EGFR signaling network: biology, prognostic value, and therapeutic implications
HW Lo - Discovery medicine, 2010 - ncbi.nlm.nih.gov
… lung cancer that carries specific EGFR mutants. Given the notion that these EGFR mutations
are absent or very rare in other cancer … Some of these efforts have led to rationales for EGFR-…
are absent or very rare in other cancer … Some of these efforts have led to rationales for EGFR-…
[HTML][HTML] Dysregulated redox regulation contributes to nuclear EGFR localization and pathogenicity in lung cancer
AC Little, M Hristova, L van Lith, C Schiffers… - Scientific Reports, 2019 - nature.com
… in various cancers, and a … lung cancers promotes dysregulated EGFR signaling and
enhanced GSTP1-mediated turnover of EGFR cysteine oxidation, which result in enhanced nuclear …
enhanced GSTP1-mediated turnover of EGFR cysteine oxidation, which result in enhanced nuclear …
Nuclear EGFR as novel therapeutic target
K Dittmann, C Mayer… - Strahlentherapie und …, 2010 - search.proquest.com
… Radiation-induced caveolin-1 and EGFR phosphorylations are associated with nuclear EGFR
… Erlotinib monotherapy in patients with advanced non-small cell lung cancer: an effective …
… Erlotinib monotherapy in patients with advanced non-small cell lung cancer: an effective …
PML represses lung cancer metastasis by suppressing the nuclear EGFR-mediated transcriptional activation of MMP2
HY Kuo, YS Huang, CH Tseng, YC Chen, YW Chang… - Cell Cycle, 2014 - Taylor & Francis
… cell invasion by decreasing the expression of MMP2, which is important for cancer … in lung
cancer cells. We report here that PML suppressed EGFR-mediated lung cancer cell invasion …
cancer cells. We report here that PML suppressed EGFR-mediated lung cancer cell invasion …
Co-encapsulated nanoparticles of Erlotinib and Quercetin for targeting lung cancer through nuclear EGFR and PI3K/AKT inhibition
… EGFR targeted therapy has proven significant clinical improvement against non-small
cell lung cancer (… of P-glycoprotein (P-gp) and nuclear epidermal growth factor receptor (nEGFR). …
cell lung cancer (… of P-glycoprotein (P-gp) and nuclear epidermal growth factor receptor (nEGFR). …
TIP30 loss enhances cytoplasmic and nuclear EGFR signaling and promotes lung adenocarcinogenesis in mice
… Moreover, TIP30 knockdown was demonstrated to enhance the survival and metastasis
potential of human lung cancer cells in vitro, and promote lung metastasis in xenograft mouse …
potential of human lung cancer cells in vitro, and promote lung metastasis in xenograft mouse …
Nuclear EGFR contributes to acquired resistance to cetuximab
C Li, M Iida, EF Dunn, AJ Ghia, DL Wheeler - Oncogene, 2009 - nature.com
… Although both strategies of inhibition have demonstrated promising antitumor activity in
patients with metastatic colorectal cancer, non-small cell lung cancer (NSCLC), breast cancer …
patients with metastatic colorectal cancer, non-small cell lung cancer (NSCLC), breast cancer …
[HTML][HTML] Epigallocatechin gallate inhibits the growth of human lung cancer by directly targeting the EGFR signaling pathway
YC Ma, C Li, F Gao, Y Xu, ZB Jiang… - Oncology …, 2014 - spandidos-publications.com
… antigen or DNA protein kinase (DNA-PK) are able to bind with nuclear EGFR and induce …
The present study identified EGFR as a direct target of EGCG in human lung cancer. EGFR …
The present study identified EGFR as a direct target of EGCG in human lung cancer. EGFR …
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