… mechanisms of therapeutic resistance is important in … lung cancer patients. In this review,
we discuss the mechanisms underlying the acquisition of resistance to different lines of therapy …

… of human cancers including lung cancer. Defects … lung tumors to radiation therapy. Here,
we will review clinically relevant mechanisms affecting resistance and sensitivity of lung cancer …

… resistance mechanisms in NSCLC targeted therapies, namely changes in the targeted
oncogenes (on-target resistance) … Therapeutic resistance limits the clinical use of chemotherapy …

… heterogeneous nature of TKI resistance, which evolves dynamically with changes in therapy.
In this … the diverse mechanisms of resistance at play in oncogene-driven lung cancers. …

… % of patients with non–small cell lung cancer. Tyrosine kinase inhibitors have provided an
… in cancer and the role of tumor-specific adaptations conferring therapeutic resistance. The …

… therapy of lung cancer, intrinsic and acquired resistance to … of mechanisms of therapeutic
resistance in lung cancer has … the crucial role of stress resistance pathways is increasingly …

… Lung cancer (LC) is one of the most frequently diagnosed malignancies and the leading
cause of cancer-related deaths in … Drug resistance has become a significant impediment to the …

… for lung cancer therapeutic responses. While PDLIM2 is epigenetically repressed in human
lung cancer, associating with therapeutic resistance and poor prognosis, its global or lung …

… resistance in lung cancer. Non-small cell lung cancer (NSCLC) cells are often intrinsically
resistant … , whereas small-cell lung cancer (SCLC) cells can acquire resistance with continued …

… drug resistance. We attempt to summarize the gap in knowledge in understanding acquired
resistance to early-phase lung cancer targeted therapy … and early adaptive drug resistance. …