The inflammatory tumor microenvironment, epithelial mesenchymal transition and lung carcinogenesis

EL Heinrich, TC Walser, K Krysan, EL Liclican… - … Microenvironment, 2012 - Springer
tumor microenvironment (TME) has many roles in tumor … in the TME, EMT and lung cancer
initiation, progression and … of inflammation and EMT in cancer prevention and treatment. …

[HTML][HTML] Early lung carcinogenesis and tumor microenvironment observed by single-cell transcriptome analysis

EY Kim, YJ Cha, SH Lee, S Jeong, YJ Choi… - Translational …, 2022 - Elsevier
… is a perfect model for studying the initiation of lung carcinogenesis, and in this study, paired
lung cancer and its microenvironment. Discriminating normal lung cells and lung cancer

The lung microenvironment: an important regulator of tumour growth and metastasis

NK Altorki, GJ Markowitz, D Gao, JL Port… - … Reviews Cancer, 2019 - nature.com
… We also discuss the potential of understanding tumour microenvironmental processes to
identify biomarkers of clinical utility and to develop novel targeted therapies against lung cancer

The microenvironment of lung cancer and therapeutic implications

V Mittal, T El Rayes, N Narula, TE McGraw… - Lung cancer and …, 2016 - Springer
… The tumor microenvironment (TME) represents a milieu that enables tumor cells to acquire
the hallmarks of cancer. The TME is heterogeneous in composition and consists of cellular …

[HTML][HTML] The role of tumor inflammatory microenvironment in lung cancer

Z Tan, H Xue, Y Sun, C Zhang, Y Song… - Frontiers in …, 2021 - frontiersin.org
Lung cancer is the most common and fatal malignant tumor in the world. The tumor
microenvironment … development of lung cancer, in which the inflammatory microenvironment plays …

IL6 blockade reprograms the lung tumor microenvironment to limit the development and progression of K-ras–mutant lung cancer

MS Caetano, H Zhang, AM Cumpian, L Gong, N Unver… - Cancer research, 2016 - AACR
… for tumor establishment (24); however, IL6 effects on tumor-… Therefore, we analyzed the
BALFs and whole lungs of CC-… immune cells within the tumor microenvironment. W&G staining of …

Tumor microenvironment is multifaceted

C Sautès-Fridman, J Cherfils-Vicini, D Damotte… - Cancer and Metastasis …, 2011 - Springer
… cell viability and induces chemosensitivity in some lung tumor cell lines. Since fresh lung
tumor cells exhibit a gene expression profile characteristic of TLR-stimulated lung tumor cell …

The effect of environmental chemicals on the tumor microenvironment

SC Casey, M Vaccari, F Al-Mulla, R Al-Temaimi… - …, 2015 - academic.oup.com
… cells were more likely to metastasize (97), indicating that carcinogens can modulate the
tumor microenvironment not just in the initiation of lung cancer but also in its progression. …

Chronic inflammation, the tumor microenvironment and carcinogenesis

TA Gonda, S Tu, TC Wang - Cell cycle, 2009 - Taylor & Francis
… In this review, we focus on the interaction between chronic inflammation, tumor stem cells
and the tumor microenvironment. We summarize the proposed mechanisms that lead to the …

[HTML][HTML] Role of tumor microenvironment in tumorigenesis

M Wang, J Zhao, L Zhang, F Wei, Y Lian, Y Wu… - … of Cancer, 2017 - ncbi.nlm.nih.gov
Tumors are encircled by extracellular matrix (ECM) and stromal cells, and the
physiological state of the tumor microenvironment (TME) is closely connected to every step of …