… In conclusion, demonstrating that pirfenidone … lung fibroblasts represent a major target of
pirfenidone in IPF treatment. Moreover, in this study we show for the first time that pirfenidone …

… -1 in human lung fibroblasts (Yoshioka et al., … action of pirfenidone on the TGF-β1-induced
expression of HSP47 and collagen in the lung using a cultured normal human lung fibroblast …

… Our findings demonstrate that the antifibrotic effects of IFN-γ and PFD on normal and IPF
lung fibroblasts are different and complementary. Combination therapy with inhaled IFN-γ and …

… The effects of the antifibrotic drug pirfenidone on … to investigate the effects of pirfenidone in
human lung fibroblast–… Human lung fibroblasts were co-cultured with human umbilical vein …

… effect of pirfenidone and rapamycin in lung epithelium, we conducted the same protocol
explained above for primary fibroblasts … with our findings in lung fibroblasts stimulated with TGF−…

… effects pirfenidone on TGF-β1-mediated contraction of ECM and migration of lung fibroblasts
isolated from patients with lung … with those of normal lung fibroblasts for understanding the …

… supernatants, pirfenidone significantly suppressed … pirfenidone suppressed polariza tion
to M2 macrophages at clinically relevant concentrations and suppressed the rat lung fibroblasts …

… human lung fibroblast proliferation and TGF-β1–induced SMAD3 expression in human lung
fibroblasts (15, 16). Surprisingly, phosphorylated SMAD3 was unchanged in lung tissue of …

Objective Pirfenidone (PFD) is an oral anti-fibrotic drug used for idiopathic pulmonary fibrosis
(IPF) therapy. We determined the role of activating transcription factor 3 (ATF3) and the …

… effects of pirfenidone on lung fibroblast to myofibroblast differentiation or other cellular sources
of fibroblasts … Moreover, in this study, inhibition of fibrocyte accumulation in the lungs was …