Mitochondrial dysfunction contributes to the senescent phenotype of IPF lung fibroblasts
M Schuliga, DV Pechkovsky, J Read… - Journal of cellular …, 2018 - Wiley Online Library
… by dysfunctional mitochondria reinforces lung fibroblast senescence … is activated, altering
mitochondrial homoeostasis and … by which mitochondria contribute to fibroblast senescence in …
mitochondrial homoeostasis and … by which mitochondria contribute to fibroblast senescence in …
Mitochondrial dysfunction in pulmonary fibrosis
S Rangarajan, K Bernard… - Annals of the American …, 2017 - atsjournals.org
… lung fibroblasts (55). Other putative mechanisms of loss of mitochondrial homeostasis in
aging/IPF lung fibroblasts … accompanies fibroblast mitochondrial dysfunction has been termed “…
aging/IPF lung fibroblasts … accompanies fibroblast mitochondrial dysfunction has been termed “…
[HTML][HTML] Mitochondria dysfunction and metabolic reprogramming as drivers of idiopathic pulmonary fibrosis
… mitochondrial dysfunction affects different lung cell populations in the context of IPF, with a
focus on epithelial cells, fibroblasts … -1α is reduced in primary lung fibroblast isolated from IPF …
focus on epithelial cells, fibroblasts … -1α is reduced in primary lung fibroblast isolated from IPF …
[HTML][HTML] Idiopathic pulmonary fibrosis: aging, mitochondrial dysfunction, and cellular bioenergetics
… with resulting mitochondrial dysfunction. Additionally, the ROS-producing enzyme NADPH
oxidase-4 (Nox4), which is upregulated in IPF lung fibroblasts, represses mitochondrial …
oxidase-4 (Nox4), which is upregulated in IPF lung fibroblasts, represses mitochondrial …
Mitochondrial dysfunction and alterations in mitochondrial permeability transition pore (mPTP) contribute to apoptosis resistance in idiopathic pulmonary fibrosis …
ER Luis-García, C Becerril, A Salgado-Aguayo… - International journal of …, 2021 - mdpi.com
… This effect was observed in our results when using attrayloside or bongkrekic acid in the
control lung fibroblasts. We observed an increase in apoptosis when stimulated …
control lung fibroblasts. We observed an increase in apoptosis when stimulated …
Mitochondrial dysfunction as a pathogenic mediator of chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis
… of mitochondrial dysfunction in epithelial cells or fibroblasts (… with mitochondrial dysfunction
in chronic lung disease … factor in normal human lung fibroblasts, such that exposure to …
in chronic lung disease … factor in normal human lung fibroblasts, such that exposure to …
Grape seed proanthocyanidins prevent irradiation-induced differentiation of human lung fibroblasts by ameliorating mitochondrial dysfunction
XH Yang, T Liu, B Chen, F Wang, Q Yang, XH Chen - Scientific Reports, 2017 - nature.com
… We next hypothesized that the mitochondrial dysfunction and generation of ROS described
above in irradiated HFL1 cells could be due to adaptations in mitochondrial respiratory ETC …
above in irradiated HFL1 cells could be due to adaptations in mitochondrial respiratory ETC …
Mitochondrial dysfunction in fibrotic diseases
X Li, W Zhang, Q Cao, Z Wang, M Zhao, L Xu… - Cell death …, 2020 - nature.com
… In lung fibroblasts, NOX4 inhibited mitochondrial bioenergetics and biogenesis through
decreasing induction and activation of endogenous nuclear factor (erythroid-derived-2)-like-2 …
decreasing induction and activation of endogenous nuclear factor (erythroid-derived-2)-like-2 …
Mitochondrial dysfunction in inflammatory responses and cellular senescence: pathogenesis and pharmacological targets for chronic lung diseases
L Yue, H Yao - British journal of pharmacology, 2016 - Wiley Online Library
… propose that mitochondrial biogenesis is needed for fibroblast … Interestingly, primary lung
fibroblasts derived from patients … , where senescent fibroblasts express increased levels of the …
fibroblasts derived from patients … , where senescent fibroblasts express increased levels of the …
The mitochondria in lung fibrosis: friend or foe?
ES Malsin, DW Kamp - Translational Research, 2018 - Elsevier
… that AEC mitochondrial dysfunction is important in mediating lung fibrosis signaling via …
profibrotic signaling required for augmenting lung fibroblast and myofibroblast populations and …
profibrotic signaling required for augmenting lung fibroblast and myofibroblast populations and …
相关搜索
- idiopathic pulmonary fibrosis mitochondrial dysfunction
- ipf lung fibroblasts senescent phenotype
- human lung fibroblasts mitochondrial dysfunction
- lung remodeling mitochondria dysfunction
- chronic lung diseases mitochondrial dysfunction
- lung ageing and disease mitochondrial dysfunction
- metabolic reprogramming mitochondria dysfunction
- transition pore mitochondrial dysfunction
- lung pathogenesis mitochondrial dysfunction
- cancer connection mitochondrial dysfunction
- fibrotic diseases mitochondrial dysfunction
- molecular pathways mitochondrial dysfunction
- mitochondrial respiratory chain dysfunction
- lung inflammaging mitochondrial redox system
- lung epithelium mitochondrial biogenesis
- lung fibrosis mitochondrial homeostasis