过去一年中添加的文章,按日期排序

Realveolarization with inhalable mucus-penetrating lipid nanoparticles for the treatment of pulmonary fibrosis in mice

Y Wang, J Zhang, Y Liu, X Yue, K Han, Z Kong… - Science …, 2024 - science.org
15 天前 - … the mitochondrial dysfunction through … lung tissue after intratracheal administration
of bleomycin for 9 days. Then, primary AT2 cells were cocultured with mouse lung fibroblasts

Pathogenic mutant LRRK2R1441G in mitochondrial dysfunction and synucleinopathy in Parkinson's disease

EES Chang - HKU Theses Online (HKUTO), 2024 - hub.hku.hk
20 天前 - … Mouse embryonic fibroblasts (MEFs) carrying … without histological abnormalities
in lung, kidney, and liver. … GNE-7915 efficacy in brain and lung. This treatment regimen …

[HTML][HTML] Extracellular vesicles activated cancer-associated fibroblasts promote lung cancer metastasis through mitophagy and mtDNA transfer

Z Zhou, C Qu, P Zhou, Q Zhou, D Li, X Wu… - Journal of Experimental & …, 2024 - Springer
25 天前 - … tumor metastasis, and mitochondrial dysfunction caused by mitochondrial DNA (mtDNA…
lung cancer, the normal fibroblasts (NFs) are activated as cancer-associated fibroblasts (…

[HTML][HTML] Inhibition of OGG1 ameliorates pulmonary fibrosis via preventing M2 macrophage polarization and activating PINK1-mediated mitophagy

W Wu, H Jia, S Chen, X Ma, S Zhou, L Qiu, X Wu… - Molecular …, 2024 - Springer
30 天前 - … OGG1 knockdown inhibits M2 macrophages-induced mitochondrial dysfunction in
lung fibroblast cells. A The conditional medium from M0/M2 macrophages was harvested and …

Immune cells crosstalk Pathways, and metabolic alterations in Idiopathic pulmonary fibrosis

P Tiwari, S Verma, KR Washimkar… - International …, 2024 - Elsevier
36 天前 - … of lipid metabolism, mitochondrial dysfunction, and adipokines in … NETs play a
crucial role in the activation of lung fibroblastsLung fibroblasts can indirectly promote fibrosis by …

Senescence and Mitochondrial Dysfunction in Lung Trisomy 21 Fibroblast

R Belgacemi, C Cherry, I El Alam… - …, 2024 - journals.physiology.org
38 天前 - … established that fibroblasts from T21 lungs present with both ER and
mitochondria-associated … Understanding this increase in senescence in the lungs of individuals …

[HTML][HTML] Acetaldehyde Dehydrogenase 2 Deficiency Aggravates Lung Fibrosis through Mitochondrial Dysfunction and Aging in Fibroblasts

Y Wei, S Gao, C Li, X Huang, B Xie, J Geng… - The American Journal of …, 2024 - Elsevier
39 天前 - … interstitial lung disease, is characterized by fibroblast activation … fibroblasts become
aberrantly activated. Here, we show acetaldehyde dehydrogenase 2 (ALDH2) in fibroblasts

PGK1 Mediates Deficient Pyruvate Utilization and Bioenergetic Compromise in Lung Fibroblasts in Age-related Lung Fibrosis

S Rangarajan, P Londono, E Turner… - … . MITOCHONDRIA …, 2024 - atsjournals.org
58 天前 - … by which PGK1 affects fibroblast pyruvate handling. Methods We studied
fibroblasts obtained from lung explants of IPF patients and rejected donor lungs. We achieved …

Mitochondrial DNA Variations May Modulate Neonatal Pulmonary Oxidative Stress and Inflammation

J Kandasamy, R Li, T Jilling… - … LUNG: MITOCHONDRIA …, 2024 - atsjournals.org
58 天前 - lung development, inflammation, and fibrosis is the commonest morbidity in very
preterm infants. Mitochondrial dysfunction … AT2 cells and neonatal mice lung fibroblasts (NMLF).…

Human Small Airway Model of COPD to Investigate Disease Mechanisms and Test Preventive Immunotherapy

M Ghaedi, R Dagher, A Moldobaeva - B70. COPD IN THE …, 2024 - atsjournals.org
58 天前 - … that accurately reflect multicellular lung tissue hinders our … in vitro small airway
with fibroblasts co-culture model, … inflammatory responses, mitochondrial dysfunction, and cell …