A multimodal imaging approach based on micro-CT and fluorescence molecular tomography for longitudinal assessment of bleomycin-induced lung fibrosis in mice

F Ruscitti, F Ravanetti, G Donofrio, Y Ridwan… - JoVE (Journal of …, 2018 - jove.com
… We propose a non-invasive imaging approach to monitor longitudinally lung fibrosis
progression by FMT and Micro-CT at different time-points after a bleomycin challenge 22 . …

Noninvasive imaging of experimental lung fibrosis

Y Zhou, H Chen, N Ambalavanan, G Liu… - American Journal of …, 2015 - atsjournals.org
… noninvasive imaging methods that are currently used for evaluation of lung fibrosis in small
… to distinguish alveolitis and pulmonary fibrosis in cadmium chloride–treated rats and in BLM-…

In-vivo lung fibrosis staging in a bleomycin-mouse model: a new micro-CT guided densitometric approach

L Mecozzi, M Mambrini, F Ruscitti, E Ferrini… - Scientific reports, 2020 - nature.com
… A total of 300 mice underwent imaging and image processing procedures, as detailed
below, in 11 drug discovery studies conducted between 2017 and 2019. Since a drug efficacy …

Improved In vivo Assessment of Pulmonary Fibrosis in Mice using X-Ray Dark-Field Radiography

A Yaroshenko, K Hellbach, AÖ Yildirim, TM Conlon… - Scientific reports, 2015 - nature.com
… a lack of sensitive imaging techniques that are able to visualize early fibrotic changes at the
… x-ray imaging approach that directly visualizes the air-tissue interfaces in mice in vivo. This …

Quantification of lung fibrosis and emphysema in mice using automated micro-computed tomography

E De Langhe, G Vande Velde, J Hostens… - 2012 - journals.plos.org
… of pulmonary fibrosis in mice using high-resolution µCT. We propose this imaging technique
… and extended our approach to emphysema. Our protocol ran fully automated and resulted …

Quantification of pulmonary fibrosis in a bleomycin mouse model using automated histological image analysis

JC Gilhodes, Y Julé, S Kreuz, B Stierstorfer, D Stiller… - PloS one, 2017 - journals.plos.org
lung fibrosis we developed an automated software histological image analysis performed
from digital image of entire lung … grading scores and digital imaging methods we developed a …

Computed tomography monitoring of radiation-induced lung fibrosis in mice

C Plathow, M Li, P Gong, H Zieher… - … radiology, 2004 - journals.lww.com
… Targeting the development of lung fibrosis before onset of clinical deterioration is a promising
approach in antifibrotic therapy, 6,7 and the benefit of different inhibitors of lung fibrosis

Lung function imaging methods in cystic fibrosis pulmonary disease

M Kołodziej, MJ de Veer, M Cholewa, GF Egan… - Respiratory …, 2017 - Springer
… mortality in CF is lung disease, it is critical that we improve pulmonary diagnosis in patients
to … 129 Xe is longer in emphysematous mouse lungs compared to healthy controls. While this …

Quantification of lung fibrosis in IPF-like mouse model and pharmacological response to treatment by micro-computed tomography

F Ruscitti, F Ravanetti, V Bertani, L Ragionieri… - Frontiers in …, 2020 - frontiersin.org
… in mice. Ex vivo reads out and micro-CT imaging were used to access lung fibrosis
approach using of relevant animal models, appropriate read outs for measuring evolution of …

From mouse to man and back: closing the correlation gap between imaging and histopathology for lung diseases

B Tielemans, K Dekoster, SE Verleden, S Sawall… - Diagnostics, 2020 - mdpi.com
… integrated approaches and novel developments in imaging, lung … , diagnose, quantify and
treat lung disease and that may be … integrated assessment of lung disease with imaging and …