… protective role of Nrf-2 against lung injury and the therapeutic potential in targeting Nrf-2. …
has been shown to play an important role in protection against oxidant associated lung injury, …

… can produce lung injury directly or indirectly and cause ALI/ARDS [7]. Direct … injury involves
a disease process that begins in the lungs by causing primarily lung damage, such as lung …

… Autopsies of the dead Nrf2 −/− mice revealed diffuse and extensive lung injury. Their lungs
were grossly enlarged and hemorrhagic, with pulmonary infiltrates and destruction of the …

… in Nrf2 (Nrf2 −/− ), a protective role for the Nrf2-ARE pathway has been demonstrated in
oxidant-mediated inflammatory lung injury … Nrf2-mediated pulmonary protection against O 2 , we …

… 2 detoxifying and antioxidant enzymes. This study was designed to determine the role of NRF2
in the pathogenesis of hyperoxic lung injury … NRF2 (Nrf2 − / − ) and wild-type mice (Nrf2 + …

… -induced lung injury. The underlying mechanisms may be closely associated with the
activation of Akt/Nrf2 and MAPK/Nrf2 antioxidative pathways and inhibition of Nrf2-independent …

… Interestingly, these mutations in NRF2 are predicted to have different effects than the Nrf2
T-… hyperoxic lung injury (10). The human 617 and 651/653-SNPs are predicted to affect NRF2 …

… We hypothesized that the ability of the Nrf2-regulated … the resolution of lung injury and
inflammation in mice lacking Nrf2 and … this defect in Nrf2 −/− mice, suggesting a critical role for …

… Nrf2 protects against intestinal I/R-induced acute lung injury … underlying acute lung injury,
we established intestinal I/R-induced lung injury in this study. The expression of Nrf2 and TLR4 …

… lung injury by inducing the Nrf2-ARE pathway. We tested the role of hydrogen in migrating
hyperoxic lung injury and its underlying mechanisms using rat and Nrf2-deficient (Nrf2 −/− ) …