Targeting lymphatic function as a novel therapeutic intervention for rheumatoid arthritis

EM Bouta, RD Bell, H Rahimi, L Xing… - … Reviews Rheumatology, 2018 - nature.com
… Dramatic changes in lymphatic vessel contraction and in the lymph nodes that drain … models
of rheumatoid arthritis (RA) During mild to moderate experimental arthritis, lymphatic vessels …

Inflammation and lymphatic function

S Schwager, M Detmar - Frontiers in immunology, 2019 - frontiersin.org
… In contrast, stimulation of the lymphatic … of rheumatoid arthritis, skin inflammation, and IBD.
Strikingly, the induced expansion of the lymphatic vasculature improves lymphatic function as …

Altered lymphatic vessel anatomy and markedly diminished lymph clearance in affected hands of patients with active rheumatoid arthritis

RD Bell, H Rahimi, HM Kenney… - … & Rheumatology, 2020 - Wiley Online Library
… Therefore, in the present study, we aimed to characterize lymphatic function and anatomy of
… impaired lymphatic function and altered lymphatic anatomy compared to healthy controls. …

Lymphatic function in autoimmune diseases

N Schwartz, MLS Chalasani, TM Li, Z Feng… - Frontiers in …, 2019 - frontiersin.org
… of the role of lymphatics in the autoimmune diseases rheumatoid arthritis, scleroderma, lupus,
… and acupuncture may be useful in improving lymphatic function in autoimmune diseases. …

Lymphatic imaging to assess rheumatoid flare: mechanistic insights and biomarker potential

H Rahimi, R Bell, EM Bouta, RW Wood, L Xing… - Arthritis Research & …, 2016 - Springer
… of draining lymphatic vessels coupled with dynamic changes in lymph node volume and flow
are characteristic features in rheumatoid arthritis (RA). Furthermore, impaired lymph egress …

Notoginsenoside R1 (NG-R1) promoted lymphatic drainage function to ameliorating rheumatoid arthritis in TNF-Tg mice by suppressing NF-κB signaling pathway

D Jiao, Y Liu, T Hou, H Xu, X Wang, Q Shi… - Frontiers in …, 2022 - frontiersin.org
… NG-R1 reduced the inflammatory cytokine production of lymphatic endothelial cells (LECs) …
NG-R1 promoted lymphatic drainage function to ameliorating rheumatoid arthritis in TNF-Tg …

[HTML][HTML] Lymphatic vessels: Roles and potential therapeutic intervention in rheumatoid arthritis and osteoarthritis

S Zhou, G Zhao, R Chen, Y Li, J Huang, L Kuang… - Theranostics, 2024 - ncbi.nlm.nih.gov
… the modulation of lymphatic function in maintaining … arthritis based on lymphatic vessels,
including the promotion of lymphangiogenesis, restoration of proper lymphatic vessel function

Lymphatic disorders in rheumatoid arthritis

E Joos, P Bourgeois, JP Famaey - Seminars in arthritis and rheumatism, 1993 - Elsevier
… Kalliom~iki J, Vastamaki M: Chronic diffuse edema of the rheumatoid hand a sign of local
lymphatic involvement. Ann Rheum Dis 27:167-169, 1968 17. Henze E, Schelbert HR, Collins …

The draining lymph node in rheumatoid arthritis: current concepts and research perspectives

F Benaglio, B Vitolo, M Scarabelli… - BioMed research …, 2015 - Wiley Online Library
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease of unknown
aetiology, leading to progressive damage of bone and cartilage with functional … Draining lymph

The role of the lymphatic system in inflammatory-erosive arthritis

EM Bouta, J Li, Y Ju, EB Brown, CT Ritchlin… - Seminars in cell & …, 2015 - Elsevier
Rheumatoid arthritis (RA) is a prevalent inflammatory joint … the popliteal lymph node (PLN)
is a biomarker of arthritic flare, … and contrast enhancement, lymphatic pulse and pumping …