Distribution of lymphatic vessels in normal and arthritic human synovial tissues

H Xu, J Edwards, S Banerji, R Prevo… - Annals of the …, 2003 - ard.bmj.com
… (VEGFR-3) for vascular endothelial growth factor C (VEGF-C), a potent stimulator of
lymphangiogenesis which has been identified in the hypertrophic synovium of arthritic joints. …

[HTML][HTML] Lymphatic vessels: Roles and potential therapeutic intervention in rheumatoid arthritis and osteoarthritis

S Zhou, G Zhao, R Chen, Y Li, J Huang, L Kuang… - Theranostics, 2024 - ncbi.nlm.nih.gov
arthritis based on lymphatic vessels, including the promotion of lymphangiogenesis, restoration
of proper lymphatic vessel … to target lymphatic vessels in treating these inflammatory joint

Altered lymphatic vessel anatomy and markedly diminished lymph clearance in affected hands of patients with active rheumatoid arthritis

RD Bell, H Rahimi, HM Kenney… - Arthritis & …, 2020 - Wiley Online Library
… We hypothesized that RA subjects with active joint disease would have impaired lymphatic
… Most importantly, our findings underscore the potential contribution of the lymphatic system to …

The role of the lymphatic system in inflammatory-erosive arthritis

EM Bouta, J Li, Y Ju, EB Brown, CT Ritchlin… - Seminars in cell & …, 2015 - Elsevier
joint inflammation and changes in the lymphatic system. … Collecting lymphatic vessels exhibit
the ability to contract, … that lymphatics are important in inflammatory-erosive arthritis, thus we …

[HTML][HTML] Lymphatic vessels in osteoarthritic human knees

DA Walsh, P Verghese, GJ Cook, DF McWilliams… - Osteoarthritis and …, 2012 - Elsevier
… of lymphatics in normal and arthritic human knees, to quantify any differences in lymphatic
… Despite this, study of lymphatics in human joint tissues has been limited by a paucity of …

Targeting lymphatic function as a novel therapeutic intervention for rheumatoid arthritis

EM Bouta, RD Bell, H Rahimi, L Xing… - Nature Reviews …, 2018 - nature.com
… the synovial lymphatic system in the context of joint homeostasis and inflammatory arthritis,
review … importance of the lymphatic system in the progression and resolution of inflammatory …

Lymphatic endothelial cells efferent to inflamed joints produce iNOS and inhibit lymphatic vessel contraction and drainage in TNF-induced arthritis in mice

Q Liang, Y Ju, Y Chen, W Wang, J Li, L Zhang… - Arthritis research & …, 2016 - Springer
… To define the cellular source of iNOS in efferent lymphatic vessels from affected joints in
TNF-Tg mice, we performed multicolor fluorescence IHC on PLNs and lymphatic vessels

Distribution and alteration of lymphatic vessels in knee joints of normal and osteoarthritic mice

J Shi, Q Liang, M Zuscik, J Shen, D Chen… - Arthritis & …, 2014 - Wiley Online Library
osteoarthritis. To investigate if there are any changes in lymphatic vessels in osteoarthritic
joints, … We examined lymphatic vessels in joints from mice 12 weeks and 20 weeks after MLI or …

Tumour necrosis factor blockade increases lymphangiogenesis in murine and human arthritic joints

K Polzer, D Baeten, A Soleiman, J Distler… - Annals of the …, 2008 - ard.bmj.com
lymphatic vessels. The role of lymphatic vessels in the arthritic synovium is as yet unclear…
In this study we examined the expression of lymphatic vessels in the arthritic synovium and …

In vivo quantification of lymph viscosity and pressure in lymphatic vessels and draining lymph nodes of arthritic joints in mice

EM Bouta, RW Wood, EB Brown… - The Journal of …, 2014 - Wiley Online Library
… However, we observed no D lymph differences in lymphatic vessels afferent to WT, … that
lymph viscosity is not a contributing factor to arthritic progression, nor a biomarker of arthritic flare…