PD-1–PD-L1 immune-checkpoint blockade in B-cell lymphomas

A Goodman, SP Patel, R Kurzrock - Nature reviews Clinical oncology, 2017 - nature.com
… of B-cell lymphomas, with a high frequency of PD-L1 positivity … of PD-L1 expression are
variable across lymphoma subtypes… widely varying rates of PD-L1 expression within the same …

[HTML][HTML] PD-L1 and PD1 expression in lymphomas

Z Gatalica, N Bilalovic, S Vranic, D Arguello, S Reddy… - Blood, 2015 - Elsevier
… -PD-L1 antibodies in histiocytoses [1], but data in lymphomas are lacking. In the current study,
we measured PD-L1 expression in lymphoma … of PD-L1 in various subtypes of lymphomas. …

PD-1/PD-L1 pathway and its blockade in patients with classic Hodgkin lymphoma and non-Hodgkin large-cell lymphomas

W Xie, LJ Medeiros, S Li, CC Yin, JD Khoury… - Current hematologic …, 2020 - Springer
PD-1/PD-L1 pathway in large-cell lymphomas, including classic Hodgkin lymphoma (CHL),
diffuse large B cell lymphoma (… -1 inhibitors, such as CHL, and specific subtypes of DLBCL. …

Programmed death-1 ligands PD-L1 and PD-L2 show distinctive and restricted patterns of expression in lymphoma subtypes

PK Panjwani, V Charu, M DeLisser, H Molina-Kirsch… - Human Pathology, 2018 - Elsevier
… the distribution of PD-L1 and PD-L2 proteins in parallel, we sought to investigate whether
these ligands show differential or interdependent expression across lymphoma subtypes. …

[HTML][HTML] Mechanisms of PD-1/PD-L1 expression and prognostic relevance in non-Hodgkin lymphoma: a summary of immunohistochemical studies

P Gravelle, B Burroni, S Péricart, C Rossi… - Oncotarget, 2017 - ncbi.nlm.nih.gov
PD-1 and PD-L1 expression, as reported by immunohistochemical staining in both non-Hodgkin
lymphoma … the predominant expression of PD-L1 in non-GCB subtypes of DLBCL NOS. …

[HTML][HTML] PD-L1 status in refractory lymphomas

S Vranic, N Ghosh, J Kimbrough, N Bilalovic, R Bender… - PloS one, 2016 - journals.plos.org
… of PD-L1 in a diverse group of refractory/relapsed lymphomas. … -PD-L1 clones and also
explored the genetic basis of PD-L1 … of PD-L1 expression across the lymphoma subtypes; thus, …

Prognostic and clinicopathological significance of PD-1/PD-L1 expression in the tumor microenvironment and neoplastic cells for lymphoma

M Xie, X Huang, X Ye, W Qian - International immunopharmacology, 2019 - Elsevier
… The clinical roles of PD-1/PD-L1 expression vary between subtypes of lymphoma. Future
studies should delineate the prognostic and predictive roles of PD-1 and PD-L1 expression. …

Genetic basis of PD-L1 overexpression in diffuse large B-cell lymphomas

K Georgiou, L Chen, M Berglund, W Ren… - Blood, The Journal …, 2016 - ashpublications.org
… of PD-L1 overexpression in DLBCL and suggest that treatments targeting the PD-1–PD-L1/PD-L2 …
DLBCL patients, especially those belonging to the more aggressive non-GCB subtype. …

PD-L1 expression is characteristic of a subset of aggressive B-cell lymphomas and virus-associated malignancies

BJ Chen, B Chapuy, J Ouyang, HH Sun… - Clinical cancer …, 2013 - AACR
… can be expressed by Reed–Sternberg cells comprising classical Hodgkin lymphoma (CHL…
PD-L1 represents a general strategy of immune evasion among aggressive B-cell lymphomas

Expression pattern of PDL1 and PD‐L2 in classical Hodgkin lymphoma, primary mediastinal large B‐cell lymphoma, and gray zone lymphoma

Y Tanaka, AM Maeshima, J Nomoto… - European Journal of …, 2018 - Wiley Online Library
lymphoma (cHL), primary mediastinal large B-cell lymphoma (PMBL), and gray zone lymphoma
(… In addition, all the cHL cases with the MC subtype (10/10) showed positivity for PD-L1