… foam cells (FC) derived from macrophages (MΦ), smooth muscle cells, and other vascular
cells … We focus on MΦ-derived foam cells, because MΦ play a central role in the atherogenic …

… To confirm that M2 macrophages differentiate into foam cells in atherosclerotic plaques in
vivo, we examined frozen sections of the aortic root from ApoE −/− mice after 8 weeks of high …

… , we examined selective macrophage differentiation occurring in areas of intraplaque
hemorrhage in human atherosclerosis relative to macrophage-derived foam cells, which contribute …

… may induce monocyte differentiation and promote foam cell formation. THP-1 cells were used
… Monocytes treated with 7-KC express markers of macrophage differentiation, phagocytose …

… differentiated macrophages as well as alveolar macrophages remained responsive to
macrophage … The M-CSF-induced macrophages resulted in enhanced foam cell formation, which …

… Foam cell targeting, anti-inflammatory therapies, such as agonists of nuclear receptors and
… of macrophage foam cell biology will hopefully enable novel foam cell targeting therapies to …

… monocytederived macrophages into foam cells by … foam cells still expressed MSR mRNA,
confirming that MSR expression is not downregulated by lipid loading (Fig 9). The foam cells …

… Furthermore, using bone marrow-derived macrophages … macrophage foam cell formation.
In conclusion, IL-33 has a protective role in atherosclerosis by reducing macrophage foam cell …

… The increase in the inflammatory potential on macrophage polar … of foam cells in development
and resolution of acute inflammation, mechanisms of their formation from macrophages …

… are central in the development of atherosclerosis, but the mechanism of foam cell formation
… macrophages. We hypothesized that TLR4 mediates macrophage differentiation to foam cells…