… production in M1-polarized macrophages) that together … macrophage metabolic response
to polarization stimuli (Figure 3). Next, we sought to investigate the function of these modules …

… metabolic adaptations are functional to support macrophage activities as well as to sustain
their polarization … is to discuss recent findings linking macrophage functions and metabolism. …

… the nutrient metabolism of macrophages affect their polarization … immune checkpoints regulate
macrophage's immune responses … of macrophage metabolism and polarization with tumor …

… for M1/M2a MΦ has been demonstrated to depend on metabolic immunomodulation [10].
M1 MΦ polarization favors aerobic glycolysis and glycolytic flux into the oxidative branch of the …

… we investigated the metabolic-epigenetic-phenotype axis following polarization of … metabolism,
protein and histone post-translational modifications, and human macrophage polarization …

… of these polarized macrophages. Experimentally silencing … macrophages polarized from
their resilient state toward the resistant state. Inhibiting these regulators in specific macrophages …

… macrophage-intrinsic or TME-produced metabolites that regulate macrophage polarization
… avenues to reprogram macrophage metabolism for mounting effective antitumor responses. …

… of phenotypic changes in macrophages. In tumors, … macrophages and in other immune
cells are also predictable. We speculate that this ‘metabolic axis’ of macrophage polarization …

… -4)–induced M0 → M2 macrophage polarization is accompanied by interchangeable glucose-
or lactate-dependent tricarboxylic acid (TCA) cycle metabolism that directly drives histone …

… , polyamine, and fatty acid metabolism. These metabolic and other key functional distinctions
… the global metabolic shifts that correlate to MΦ functional plasticity in these phenotypes. …