… Glycine transporters may become major targets for therapeutic … changes described for other
neurotransmitter systems, these changes may support some of the effects observed in glycine…

… For GlyT2, glycine transport is unlikely to be reversed by changes in the intracellular ionic …
In conclusion, although astrocytes seem to constitute the major cell type in which the GlyT1 …

… Glycine is a major inhibitory neurotransmitter in the mammalian CNS (central nervous … − is
thought to induce a conformational change that switches the transporters from an ‘outward’ to …

… of GLYT1b and GLYT2a, the major glycine transporter isoforms in the CNS. … changes of the
first external loop in the glycine transporters. The external loop one of the glycine transporters …

… mediated by glutamate, the major excitatory neurotransmitter in the … changes might affect
the metabolism of glycine or the contribution of GLYT1 in humans. Finally, glycine transporters …

… on the basis of a 2 charges/glycine flux ratio and changes in the reversal potential of the …
Glycine is one of the major inhibitory neurotransmitters in spinal cord and brainstem …

… persistent elevation of synaptic glycine at Schaffer collateral–… with reduced expression of
glycine transporter type 1 (GlyT1+/−… Surprisingly, this change was associated with a reduction in …

… To examine the role that Cl − plays in the transport cycle, we measured the effect of Cl − on
both glycine binding and conformational changes. The ability of glycine to displace the high-…

… Glycine is the major inhibitory neurotransmitter in brainstem … of glycine is largely under control
of glycine transporter 1 (… , we hypothesized that changes in hippocampal GlyT1 expression …

… , suggesting that the intracellular concentrations of glycine, Na + , and Cl − did not change …
A direct evaluation of stoichiometry was obtained by studying E Rev changes as a function of …