… In this perspective article, the authors discuss the recent development of targeted cancer
drugs and identify major hurdles. The authors further highlight future strategies that might …

… target and identification/development of novel antifungal lead molecule aiming multiple
molecular targets of … of target proteins and mutations in the target are the major cause of multiple …

… against mycobacteria, to discovering new molecular targets by genetic manipulation. This
… to try to identify new molecules or targets that are able to impair M. tuberculosis survival. …

… , to bring HDAC inhibitors to market for every major tumor type, both solid and hematologic.
At … , revealing for the first time the drug's molecular target. This explained why SAHA usually …

… The most important consequence, and the major difference … The surface targets used
today are mostly present to a certain … The effector molecule is a small molecule designed to …

… major aspects—targeting EPS, dispersal molecules, … hurdles in the development of biofilm
dispersal agents in order to provide a rationale for multi-targeted therapy strategies that target …

… from three to fifteen folate molecules have shown a … major challenge is the issue of
heterogeneity, where different regions of a tumor may have varying levels of expression of the target …

… review procedure for products of major therapeutic interest. In … Another major difference
between nations is the disparity in … , to shed targets or accessory molecules in ways that allow …

… Importantly, two major strategies take either a gene expression or drug-target approach.
For … from human cells treated with various bioactive small molecules (12). Studying a drug’s …

… Poor oral bioavailability is the major hurdle faced by potential phytomolecules to be … on
multiple targets and this off-target activity may become a safety concern. Molecules below the …