… A major problem in conventional cancer therapies is the development of drug resistance. …
reasonable molecular targets and establish optimal dose. In addition to molecular targets, other …

… isolation and characterization, and the molecular mechanisms governing their self-renewal …
of their downstream target genes. Thus, the roles of major target genes identified are …

… an important target for the therapy of HCV infection. BMS-824 is a small molecule which targets
… To circumvent this major hurdle in HCV therapy, the current research efforts are aimed at …

… be developed that are based on molecular networks of healthy or … molecules that target
different physiological or molecular … to identify different key molecular targets involved in the …

… ICIs target unique inhibitory checkpoint molecules expressed by T- and antigen-presenting
cells. By blocking those receptors, ICIs promote the proper induction and differentiation of T …

… The major problem in drug delivery to the brain is the … including all large-molecule and
some small-molecule drugs also1. … only within the target tissue but also elsewhere in the body. …

… out the hurdles that must be overcome in bringing molecular … the presence of appropriate
molecular targets; to confirm … That there remain major technical challenges to molecular …

… hurdles in high-throughout discovery programs, including … , a major bottleneck in the drug
discovery process remains … in uncovering the molecular target of biologically active molecules. …

… , targeting RNA with small molecules has no major conceptual hurdles to overcome. Proof
of … provide a perfectly useful set of molecular targets for small molecules that bind to RNA. …

… One of the major advantages of RNAi is the capability to access “non-druggable” targets; for
… The siRNA molecule developed to target different viral genes including gag, tat, nef, vif, rev …