… One of the major advantages of RNAi is the capability to access “non-druggable” targets; for
… The siRNA molecule developed to target different viral genes including gag, tat, nef, vif, rev …

… will benefit from a detailed molecular understanding of the … identified new candidate therapeutic
targets and approaches. It … This analysis revealed two major subsets of tumors that were …

… been identified as potential new targets. This review provides … of major signaling pathways
that could represent targets for … In this regard, a better understanding of molecular survival …

… ) two major technical hurdles. One is … target(s) of the bioactive molecule. The reviews
presented in this issue of Chemistry & Biology cover a number of different approaches to the target …

… molecular targets. Protein-protein interactions are likely to represent one of the next major
classes of therapeutic targets… Despite major hurdles in specifically targeting transcription factor …

… In this review, we provide an overview of the major mechanisms used by tumor cells to … with
the TME will allow for the identification of novel molecular targets in CAR-T cells design (344)…

… One major hurdle in assessing the efficacy of such drugs has been the inability to sense
or image anti-proteinase activity directly and non-invasively in vivo. We show here that novel, …

… systems worldwide, which is a major concern in this research’s field. … in delivering its genetic
load to the target cell or organ. … Entering the nuclear envelope efficiently requires a molecule …

… edible transgenic plant material, but one major hurdle is the need to ensure an appropriate
… to exclude a priori major crop plants as hosts, particularly if the target molecule poses little or …

… Rapidly evolving nature of ATMPs and the lack of regulatory knowledge are major hurdles
… MHC-I molecules on target cells and are activated when the expression of MHC-I molecules …