Genetic diversity and protective efficacy of the RTS, S/AS01 malaria vaccine

DE Neafsey, M Juraska, T Bedford… - … England Journal of …, 2015 - Mass Medical Soc
… The RTS,S/AS01 vaccine targets the … has partial protective efficacy against clinical and
severe malaria disease in infants and children. We investigated whether the vaccine efficacy was …

Correlates of malaria vaccine efficacy

DI Stanisic, MBB McCall - Expert Review of Vaccines, 2021 - Taylor & Francis
efficacy against controlled human malaria infections (CHMI) and against naturally acquired
infections. Expert Opinion: Effective vaccination … disappointing efficacy of malaria vaccine

Malaria prevention: from immunological concepts to effective vaccines and protective antibodies

IA Cockburn, RA Seder - Nature immunology, 2018 - nature.com
… that must be overcome to improve malaria-vaccine efficacy with current approaches. This …
review of all malaria-vaccine trials or to encompass the field of transmission-blocking vaccines (…

Reduced protective efficacy of a blood-stage malaria vaccine by concurrent nematode infection

Z Su, M Segura, MM Stevenson - Infection and immunity, 2006 - Am Soc Microbiol
efficacy of malaria vaccines in humans. We established a murine coinfection model involving
blood-stage Plasmodium chabaudi AS malaria … the protective efficacy of a malaria vaccine. …

The RTS, S malaria vaccine

S Casares, TD Brumeanu, TL Richie - Vaccine, 2010 - Elsevier
protection afforded by RTS,S and to build a more efficacious second generation vaccine
against malaria… This review will focus on current knowledge about the protective efficacy of RTS,…

Vaccine efficacy: winning a battle (not war) against malaria

P Van de Perre, JP Dedet - The Lancet, 2004 - thelancet.com
… Not only is the burden of malaria, mainly in HIV-infected pregnant women, increasing, but …
might need a malaria vaccine might also be an obstacle to vaccine effectiveness, because of …

Evaluation of SPf66 malaria vaccine efficacy in Brazil

M Urdaneta, A Prata, CJ Struchiner, CE Tosta, P Tauil… - 1998 - arca.fiocruz.br
… is to be a public health tool, we cannot base our conclusions on its efficacy against the
first episode, but on its overall efficacy. Overall protective efficacies of SPf66 malaria vaccine

Pre-erythrocytic malaria vaccines: towards greater efficacy

AVS Hill - Nature Reviews Immunology, 2006 - nature.com
… current malaria vaccine reaches the levels of durable efficacy likely to be required for vaccine
… -liver-stage vaccines in combination produces much greater efficacy and this combination …

Long-term efficacy and immune responses following immunization with the RTS, S malaria vaccine

JA Stoute, KE Kester, U Krzych… - The Journal of …, 1998 - academic.oup.com
… The RTS,S malaria vaccine formulations we studied were designed to induce strong
immune responses to the P. falciparum CS antigen. Our data indicate that antibody and cellular …

Correlating efficacy and immunogenicity in malaria vaccine trials

MBB McCall, PG Kremsner, B Mordmüller - Seminars in Immunology, 2018 - Elsevier
protection in malaria vaccine development: Does immunogenicity predict malaria vaccine
efficacy … Have immunological correlates accelerated malaria vaccine development in the past …