RTS, S: the first malaria vaccine

F Zavala - The Journal of clinical investigation, 2022 - Am Soc Clin Investig
… , and the estimated protective efficacy was 29% by proportional analysis (11). A recent trial
of this attenuated sporozoite vaccine in Kenya failed to demonstrate significant efficacy in 5- …

New antigens for a multicomponent blood-stage malaria vaccine

FH Osier, MJ Mackinnon, C Crosnier, G Fegan… - Science translational …, 2014 - science.org
protective efficacy (PPE) against clinical episodes of malaria in a … were predictive of high
levels of protection. Our data suggest that … In this analysis, 100% protective efficacy refers to the …

Advances in malaria vaccine development: report from the 2017 malaria vaccine symposium

CH Coelho, JYA Doritchamou, I Zaidi, PE Duffy - npj Vaccines, 2017 - nature.com
Malaria Vaccine Symposium. In this meeting report, we highlight the progress on different
malaria vaccine … and genetic findings that may impact malaria vaccine responses and efficacy. …

Sterile protection against human malaria by chemoattenuated PfSPZ vaccine

B Mordmüller, G Surat, H Lagler, S Chakravarty… - Nature, 2017 - nature.com
… 1a) and based on the previous data with PfSPZ Vaccine, we hypothesize that increasing
numbers of PfSPZ per dose will increase protective efficacy to 100% with the 10-day regimen. …

What will a partly protective malaria vaccine mean to mothers in Africa?

JE Epstein - The Lancet, 2007 - thelancet.com
… In today's Lancet, John Aponte and colleagues report that the candidate malaria vaccine
RTS,S… -protective efficacy. In Gambian adults, vaccine efficacy was 71% in the 9 weeks after last …

Evidence of blood stage efficacy with a virosomal malaria vaccine in a phase IIa clinical trial

FM Thompson, DW Porter, SL Okitsu, N Westerfeld… - PLoS …, 2008 - journals.plos.org
… evidence of pre-erythrocytic stage efficacy in phase IIa trials [8]… vaccine-induced blood stage
protection for the first time in a challenge study. This study also shows that protective efficacy

Malaria vaccines: recent advances and new horizons

SJ Draper, BK Sack, CR King, CM Nielsen, JC Rayner… - Cell host & …, 2018 - cell.com
… RTS,S, formulated with the potent liposomal adjuvant system AS01 from GlaxoSmithKline,
is the only vaccine that has demonstrated protective efficacy against clinical malaria in a …

Molecular basis of allele-specific efficacy of a blood-stage malaria vaccine: vaccine development implications

A Ouattara, S Takala-Harrison, MA Thera… - The Journal of …, 2013 - academic.oup.com
efficacy against clinical malaria in a phase II trial in Malian children. We assessed the
cross-protective efficacy of the malaria vaccine … AMA1 were the targets of protective allele-specific …

Vaccination with SPf66, a chemically synthesised vaccine, against Plasmodium falciparum malaria in Colombia

MV Valero, LR Amador, C Galindo, J Figueroa… - The Lancet, 1993 - Elsevier
… 168 and 297 episodes of Plasmodium falciparum malaria were documented in the SPf66 …
crude protective efficacy of 38·8%. Incidence rates for first or only P falciparum malarial

Advances and challenges in malaria vaccine development

R Wang, JD Smith, SHI Kappe - Expert reviews in molecular …, 2009 - cambridge.org
… to fail or confer only limited protection, the delivery of an efficacious wholecell, live-attenuated
malaria vaccine is likely to be a critical tool by which we can hope to eradicate malaria. …