[HTML][HTML] Immune mechanisms in malaria: new insights in vaccine development
EM Riley, VA Stewart - Nature medicine, 2013 - nature.com
… given the relatively low efficacy of the vaccine, this needs to … for malaria vaccines and the
recent history of malaria vaccine … design of more effective malaria vaccines will be accelerated …
recent history of malaria vaccine … design of more effective malaria vaccines will be accelerated …
Malaria vaccines
R Amador, ME Patarroyo - Journal of clinical immunology, 1996 - Springer
… a protective efficacy ranging between 38.8 and 60.2% against Plasmodium falciparum malaria…
a central role in the evaluation of the protective efficacy and side effects of the new malaria …
a central role in the evaluation of the protective efficacy and side effects of the new malaria …
The RTS, S malaria vaccine: Current impact and foundation for the future
JG Beeson, L Kurtovic, C Valim, KP Asante… - Science Translational …, 2022 - science.org
… with vaccine efficacy in multiple clinical trials across malaria-endemic study sites (5),
although the precise concentration threshold and mechanisms for protection remain unclear. …
although the precise concentration threshold and mechanisms for protection remain unclear. …
[HTML][HTML] A viral-vectored multi-stage malaria vaccine regimen with protective and transmission-blocking efficacies
Y Yusuf, T Yoshii, M Iyori, H Mizukami… - Frontiers in …, 2019 - frontiersin.org
… the long-term protective efficacy of the regimen … protective efficacy is lower than the
protective efficacy observed here, this regimen could still be a great tool for supporting the malaria …
protective efficacy observed here, this regimen could still be a great tool for supporting the malaria …
[HTML][HTML] Protective efficacy and safety of liver stage attenuated malaria parasites
… attenuation relates to vaccine efficacy. Here, we generated rodent malaria parasite lines …
impact of multiple gene deletions on attenuation and protective efficacy. In contrast to P. berghei …
impact of multiple gene deletions on attenuation and protective efficacy. In contrast to P. berghei …
Efficacy of RTS, S/AS01E malaria vaccine and exploratory analysis on anti-circumsporozoite antibody titres and protection in children aged 5–17 months in Kenya and …
… the lead candidate malaria vaccine. We recently showed efficacy against clinical falciparum
malaria in 5… We aimed to assess the efficacy of RTS,S/AS01E during 15 months of follow-up. …
malaria in 5… We aimed to assess the efficacy of RTS,S/AS01E during 15 months of follow-up. …
Enhanced CD8 T cell immunogenicity and protective efficacy in a mouse malaria model using a recombinant adenoviral vaccine in heterologous prime–boost …
SC Gilbert, J Schneider, CM Hannan, JT Hu… - Vaccine, 2002 - Elsevier
… vaccine was capable of boosting to protective levels a CD8 + T cell response primed by either
a plasmid DNA vaccine, a recombinant Ty virus-like particle vaccine or … protective efficacy …
a plasmid DNA vaccine, a recombinant Ty virus-like particle vaccine or … protective efficacy …
Multifunctional antibodies are induced by the RTS, S malaria vaccine and associated with protection in a phase 1/2a trial
… improve the protective efficacy of RTS,S or other malaria vaccines. … protective associations
identified in this study, and to define correlates of protection from infection and clinical malaria. …
identified in this study, and to define correlates of protection from infection and clinical malaria. …
Malaria vaccines: past, present and future
L Von Seidlein, P Bejon - Archives of disease in childhood, 2013 - adc.bmj.com
… a vaccine protective efficacy at 8 -month follow-up of 56% (99% CI 31% to 72%, p<0.001)
against all malaria … 50% protection against falciparum malaria in children vaccinated at over 5 …
against all malaria … 50% protection against falciparum malaria in children vaccinated at over 5 …
[HTML][HTML] Malaria vaccine efficacy: the difficulty of detecting and diagnosing malaria
WP O'Meara, BF Hall, FE McKenzie - Malaria journal, 2007 - Springer
… obstacle in evaluating malaria vaccines is the difficulty of diagnosing clinical malaria. This
… of efficacy trials of malaria vaccines and make recommendations for improving future trials. …
… of efficacy trials of malaria vaccines and make recommendations for improving future trials. …