… given the relatively low efficacy of the vaccine, this needs to … for malaria vaccines and the
recent history of malaria vaccine … design of more effective malaria vaccines will be accelerated …

… a protective efficacy ranging between 38.8 and 60.2% against Plasmodium falciparum malaria…
a central role in the evaluation of the protective efficacy and side effects of the new malaria …

… with vaccine efficacy in multiple clinical trials across malaria-endemic study sites (5),
although the precise concentration threshold and mechanisms for protection remain unclear. …

… the long-term protective efficacy of the regimen … protective efficacy is lower than the
protective efficacy observed here, this regimen could still be a great tool for supporting the malaria …

… attenuation relates to vaccine efficacy. Here, we generated rodent malaria parasite lines …
impact of multiple gene deletions on attenuation and protective efficacy. In contrast to P. berghei …

… the lead candidate malaria vaccine. We recently showed efficacy against clinical falciparum
malaria in 5… We aimed to assess the efficacy of RTS,S/AS01E during 15 months of follow-up. …

… vaccine was capable of boosting to protective levels a CD8 + T cell response primed by either
a plasmid DNA vaccine, a recombinant Ty virus-like particle vaccine or … protective efficacy …

… improve the protective efficacy of RTS,S or other malaria vaccines. … protective associations
identified in this study, and to define correlates of protection from infection and clinical malaria. …

… a vaccine protective efficacy at 8 -month follow-up of 56% (99% CI 31% to 72%, p<0.001)
against all malaria … 50% protection against falciparum malaria in children vaccinated at over 5 …

… obstacle in evaluating malaria vaccines is the difficulty of diagnosing clinical malaria. This
… of efficacy trials of malaria vaccines and make recommendations for improving future trials. …