Can growth inhibition assays (GIA) predict blood-stage malaria vaccine efficacy?

CJA Duncan, AVS Hill, RD Ellis - Human vaccines & …, 2012 - Taylor & Francis
… ,Citation 25 - Citation 28 however the most effective malaria vaccine to date has … ) vaccine
RTS,S, which is the only candidate malaria vaccine to have progressed to phase III efficacy

Malaria vaccines in the eradication era: current status and future perspectives

KL Wilson, KL Flanagan, MD Prakash… - … review of vaccines, 2019 - Taylor & Francis
efficacious and long-lasting malaria vaccine is required. The licensing of RTS, S/AS01 is a
step forward in providing some protection, but a malaria vaccine … advances in malaria vaccine

Safety and efficacy of PfSPZ Vaccine against Plasmodium falciparum via direct venous inoculation in healthy malaria-exposed adults in Mali: a randomised, double …

MS Sissoko, SA Healy, A Katile, F Omaswa… - The Lancet infectious …, 2017 - thelancet.com
… infection in malaria-naive individuals. We aimed to assess the safety and protective efficacy
of PfSPZ Vaccine against naturally acquired P falciparum in malaria-experienced adults in …

[HTML][HTML] Efficacy and safety of the RTS, S/AS01 malaria vaccine during 18 months after vaccination: a phase 3 randomized, controlled trial in children and young …

RTS, S Clinical Trials Partnership (2014) - PLoS medicine, 2014 - journals.plos.org
… A malaria vaccine could be an important addition to current … vaccine efficacy (VE) of the
RTS,S/AS01 vaccine during 18 mo following vaccination at 11 African sites with varying malaria

The path of malaria vaccine development: challenges and perspectives

C Arama, M Troye‐Blomberg - Journal of internal medicine, 2014 - Wiley Online Library
… of cheap, affordable and efficacious malaria vaccines 3. Because of the large gap in our
understanding of the biology of P. falciparum infection, it is difficult to identify the right …

[HTML][HTML] Safety and efficacy of malaria vaccine candidate R21/Matrix-M in African children: a multicentre, double-blind, randomised, phase 3 trial

MS Datoo, A Dicko, H Tinto, JB Ouédraogo… - The Lancet, 2024 - thelancet.com
… that a new malaria vaccine, R21/Matrix-M, had over 75% efficacy against clinical malaria with
… Here, we report on safety and efficacy of the vaccine in a phase 3 trial enrolling over 4800 …

[HTML][HTML] Malaria vaccines and their potential role in the elimination of malaria

GA Targett, BM Greenwood - Malaria Journal, 2008 - Springer
vaccine that has a protective efficacy of more than 50% against severe disease and death
from malaria … Secondly, by 2025, to develop a vaccine with a protective efficacy greater than 80…

[HTML][HTML] The time-course of protection of the RTS, S vaccine against malaria infections and clinical disease

MA Penny, P Pemberton-Ross, TA Smith - Malaria journal, 2015 - Springer
… This trial provides estimates of efficacy against clinical malaria, but does not … protection
against infection or of the dynamics of protection over time. Mathematical models of malaria

[HTML][HTML] Malaria vaccines: from the past towards the mRNA vaccine era

ME Tsoumani, C Voyiatzaki, A Efstathiou - Vaccines, 2023 - mdpi.com
… development of a highly efficacious malaria vaccine. The recent success of mRNA-based …
overview of the malaria vaccines’ evolution from the past towards the mRNA vaccine era and …

Induction of CD8+ T cell responses and protective efficacy following microneedle-mediated delivery of a live adenovirus-vectored malaria vaccine

FE Pearson, C O'Mahony, AC Moore, AVS Hill - Vaccine, 2015 - Elsevier
… ME-TRAP induces high levels of protection against malaria parasite challenge Finally, we
assessed the protective efficacy of microneedle delivery of ChAd63.ME-TRAP in a ChAd63/…