Safety and efficacy of a typhoid conjugate vaccine in Malawian children

PD Patel, P Patel, Y Liang, JE Meiring… - … England Journal of …, 2021 - Mass Medical Soc
… -TCV) in diverse epidemiologic settings in Malawi, Nepal, and Bangladesh. Here, we present
the efficacy results and safety outcomes from a clinical trial in Malawi of a single dose of Vi-…

Safety and immunogenicity of a typhoid conjugate vaccine among children aged 9 months to 12 years in Malawi: a nested substudy of a double-blind, randomised …

N Nampota-Nkomba, OM Nyirenda… - The Lancet Global …, 2022 - thelancet.com
… TCV is safe and highly immunogenic in Malawian children 9 … Malawian children aged 9
months to 12 years. The primary objective of the parent study was to measure TCV efficacy in …

Efficacy of typhoid conjugate vaccine: final analysis of a 4-year, phase 3, randomised controlled trial in Malawian children

PD Patel, Y Liang, JE Meiring, N Chasweka, P Patel… - The Lancet, 2024 - thelancet.com
… In this phase 3, double-blind, randomised controlled efficacy trial in Blantyre, Malawi,
healthy children aged 9 months to 12 years were randomly assigned (1:1) by an unmasked …

… Consortium Malawi: a phase III, randomized, double-blind, controlled trial of the clinical efficacy of typhoid conjugate vaccine among children in Blantyre, Malawi

JE Meiring, MB Laurens, P Patel, P Patel… - Clinical Infectious …, 2019 - academic.oup.com
children in countries with a high burden of disease. This study aims to determine the efficacy
… Health Organization, by testing it in children 9 months through 12 years of age in Blantyre, …

Sulfadoxine-pyrimethamine–based combinations for malaria: a randomised blinded trial to compare efficacy, safety and selection of resistance in Malawi

DJ Bell, SK Nyirongo, M Mukaka, EE Zijlstra… - PLoS …, 2008 - journals.plos.org
… In Malawi, there has been a return of Plasmodium falciparum sensitivity to chloroquine (…
safe for treatment and is increasingly being used in Africa. Here we compare the efficacy, safety

Efficacy of human rotavirus vaccine against severe gastroenteritis in Malawian children in the first two years of life: a randomized, double-blind, placebo controlled trial

NA Cunliffe, D Witte, BM Ngwira, S Todd, NJ Bostock… - Vaccine, 2012 - Elsevier
… undertaken in Malawi and South … efficacy in the Malawi cohort of children who were followed
into the second year of life. A total of 1773 healthy infants were enrolled in Blantyre, Malawi

Monitoring the efficacy of artemether-lumefantrine for the treatment of uncomplicated malaria in Malawian children

R Dambe, J Sande, D Ali, B Chilima, W Dodoli… - Malaria Journal, 2015 - Springer
efficacy and safety of AL for the treatment of uncomplicated Plasmodium falciparum malaria
among six to 59 months old Malawian children. … was high efficacy of AL in Malawi. Therefore, …

Efficacy of sulphadoxine/pyrimethamine for Plasmodium falciparum malaria in Malawian children under five years of age

OC Nwanyanwu, C Ziba, P Kazembe… - Tropical Medicine & …, 1996 - Wiley Online Library
children treated with SP in Mangochi and Karonga. SP should therefore be retained as first
line drug for malaria treatment in Malawi; however, its efficacy … assessment of efficacy should …

Safety and efficacy of rituximab in patients with diffuse large B-cell lymphoma in Malawi: a prospective, single-arm, non-randomised phase 1/2 clinical trial

S Kimani, MS Painschab, B Kaimila… - The Lancet Global …, 2021 - thelancet.com
… We aimed to establish the safety and efficacy of rituximab plus cyclophosphamide,
doxorubicin, vincristine, and prednisone (R-CHOP) in patients with DLBCL in Malawi. …

Bubble continuous positive airway pressure for children with high-risk conditions and severe pneumonia in Malawi: an open label, randomised, controlled trial

ED McCollum, T Mvalo, M Eckerle, AG Smith… - The Lancet …, 2019 - thelancet.com
… hospital mortality among high-risk Malawian children with severe pneumonia, compared
with … deteriorating on oxygen did not receive rescue bCPAP as bCPAP efficacy had not been …