… nicotinamide (NA) and streptozotocin (STZ). The mechanism underlying diabetes induction
by combining the two chemicals involves blunting the toxic effect of STZ … /kg STZ in a mouse …

… of both streptozotocin (STZ) and nicotinamide (NA) has been proposed to induce experimental
diabetes in the rat. STZ is … to rats to partially protect insulin-secreting cells against STZ. …

… islets in streptozotocin-nicotinamide (STZ-NA) diabetic mice. Seventy adult male NMRI mice
… by intraperitoneal injection of streptozotocin 50 mg/kg after a dose of nicotinamide 120 mg/…

… Nicotinamide In a preliminary experiment, we determined an optimum dosing and schedule
for administering STZ and NA, with male C57/BL6J mice of 6 week old age. Mice were …

… in type 2 diabetic male cases [1]. Indeed, the findings of the present study revealed that
STZ-NA-induced diabetes can produce male reproductive dysfunction through changes to …

… nicotinamide mononucleotide (NMN) on testicular spermatogenic function in streptozotocin
(STZ)-… by random selection of 50 cross sections of the seminiferous tubules from each mouse. …

… Male C57BL/6 mice were administered with three different doses of STZ (65, 75, and 100
mg/kg … Isonicotinamide inhibited STZ-induced cell death in cultured mouse islets. Isolated islets …

… mouse model by the simultaneous treatment of NA and STZ (… to STZ because there are
differences among mouse strains in … -cells that are related to sensitivity of their mice to STZ (4). NA/…

… In conclusion, NAM showed a protective effect on skeletal muscle atrophy in STZ-induced
diabetic mice, which may be through inhibition of TGF-β1/Smad2 pathway. We believe that our …

… SLN on streptozotocin-nicotinamide- (STZ-NA-) induced T2DM of the mouse and hyperglycemic
… Then, 120 adult male NMRI mice were divided into 7 groups: control, vehicle, diabetes (…