Immortalization of human cells and their malignant conversion by high risk human papillomavirus genotypes

H zur Hausen - Seminars in cancer biology, 1999 - Elsevier
… in malignant conversion, although, in spite of being necessary, they are not sufficient for the
development of the malignant … the process towards malignant conversion, usually covering a …

Characteristics of the lesions and risk of malignant conversion associated with the type of human papillomavirus involved in epidermodysplasia verruciformis

G Orth, S Jablonska, M Jarzabek-Chorzelska, S Obalek… - Cancer Research, 1979 - AACR
… to correlate the type of human papillomavirus (HPV) found in … or abortive and showed
no malignant conversion. HPV type 4 … One of these patients had early malignant lesions (Bowen's …

Human papillomaviruses and associated malignancies.

RM Alani, K Münger - Journal of clinical oncology, 1998 - ascopubs.org
… The human papillomaviruses (HPVs) are small DNA tumor … with the development of epithelial
malignancies. Greater than 90% of … basis for HPV-associated malignancies. Although many …

Papillomaviruses in human cancers

H Zur Hausen - Proceedings of the Association of American …, 1999 - Wiley Online Library
… For almost 70 additional years, the various forms of human warts … caused by the same agent,
human papillomavirus (HPV). … malignant conversion is further underlined by the malignant

Human papillomaviruses

H Zur Hausen, EM De Villiers - Annual review of microbiology, 1994 - go.gale.com
… Similarly, malignant conversion of HPV 16-immortalized human cells has been recorded
after exposure to low-dose X-irradiation or after treatment with chemical carcinogens (M Durst, …

The human papillomavirus E6 protein and its contribution to malignant progression

F Mantovani, L Banks - Oncogene, 2001 - nature.com
… The Human Papillomavirus (HPV… malignant conversion of virally infected cells. In order to
understand the mechanisms by which E6 contributes to the development of human malignancy

Progression of human papillomavirus type 18-immortalized human keratinocytes to a malignant phenotype.

PJ Hurlin, P Kaur, PP Smith… - Proceedings of the …, 1991 - National Acad Sciences
… of human epithelial cells to malignancy, using a human papillomavirus type 18 (HPV-18)-immortalized
human … The progression to malignancy was associated with an increase in the …

Human papillomavirus and human disease

KR Beutner, S Tyring - The American journal of medicine, 1997 - Elsevier
malignancies. In the 1980s, however, attention turned once again to the ability of papillomaviruses
to mediate malignant conversion of … with certain types of human papillomavirus (HPV) …

Six1 promotes epithelial–mesenchymal transition and malignant conversion in human papillomavirus type 16-immortalized human keratinocytes

H Xu, Y Zhang, D Altomare, MM Peña, F Wan… - …, 2014 - academic.oup.com
… DR resulted in malignant conversion and increased the cancer stem cell (CSC)-like population.
Thus, Six1 overexpression promotes EMT, CSCs properties and malignant conversion in …

Human papillomavirus oncoproteins: pathways to transformation

CA Moody, LA Laimins - Nature reviews cancer, 2010 - nature.com
… in malignant progression. The importance placed on understanding the contribution of HPV
infection to malignant … genetic alterations are needed for malignant progression 4 . The HPV …