… resistance (MDR)1 to mammalian tumor cells. These large plasma membrane proteins
confer drug resistance by actively extruding a range of cytotoxic drugs from the cell. Transported …

… overall pharmacokinetics of drugs and hormones in the body, brain CYP could play … drugs
or xenobiotics. We have characterized the CYP-dependent metabolism of l-deprenyl by brain …

… of these drugs on the … of drugs on the responses of adult and immature mammals. The
results of these experiments suggest that many psychoactive compounds thought to act on brain …

… It is the central role that these ubiquitous proteins play as phase I enzymes in mammalian
drug metabolism, steroidogenesis, the metabolism of fatty acids and the conversion of …

… Understanding the processes explaining the poor brain penetration of bumetanide is needed
for developing strategies to improve the brain delivery of this drug. In the present study, we …

… in the mammalian brain. Moreover, we will describe the findings concerning d-Asp metabolic
… of embryonic cerebral d-Asp metabolism in modulating brain morphology and functioning. …

… also in brain parenchyma. The novel localization of drug transporters in brain parenchyma
… of the present conceptualization of brain barriers as it relates to drug transport. That is, the …

… From an evolutionary point of view, a comparison of glucose and oxygen metabolic rates
of the adult brain in awake mammals (rodents, macaque, baboon) suggests that the total …

… rat brain, agmatine, AGM and ALP are predominantly localised in areas associated with roles
in appetitive and craving (drug… a view to their role in the agmatine metabolism in mammals. …

… brain reported herein provides new insights into drug metabolism that builds a foundation for
… studies in diverse research fields focused on neurological disorders and drug metabolism. …