… , abused other drugs as well, and interactions among drugs could affect the patterns of
regional brain glucose metabolism. Third, the pattern of metabolic dysfunction after prolonged …

… functional significance of brain GABA metabolism using isolated … as metabolic substrates,
we show that both mouse and human brain slices exhibit a large capacity for GABA metabolism…

… brain. These complementary demonstrations of neurofeedback stimulated the notion of
unlimited plasticity of the mammalian brain … -regulation of the disordered brain regions. However, …

… and drug-metabolizing enzymes were measured in livers and placentas of different mammal
… , as were the activities of drug-oxidizing enzymes. Human fetal liver contained an intact …

Myelin alteration is thought to be the primary pathologic characteristic of phenylketonuria.
Clinical symptoms and histologic changes in brain suggest that neuronal insult also may be …

… metabolism and biology of bioactive sphingosine 1-phosphate as novel targets for the
development of therapeutic paradigms and the discovery of new drugs… sphingolipids in mammals, …

… Inhaled anesthetics bind specifically to many proteins in the mammalian brain. … drugs, we
examined changes in protein expression after anesthetic exposure in both intact rodent brains …

… ,has been found to occur in the brains of mouse, rat, … brains of all mammals and that
conclusions drawn from its behaviour in one type of brain may be applied to other mammalian brains …

… to study PSM intake in a variety of mammalian study systems. Here, we describe several …
of drugs in human that have potential to further advance knowledge of mammalian herbivore…

… mammalian metabolism of GHB. To achieve our objectives, we first evaluated GHB metabolism
in … Despite its expanding role as therapeutic agent and drug of abuse, surprisingly little is …