Our understanding of the detailed recognition and processing of clinically useful therapeutic
agents has grown rapidly in recent years, and we are now able to begin to apply this …

… sequence of the mammalian carboxylesterases shows that … and classification of mammalian
carboxylesterase. Until … valid links among the mammalian carboxylesterase gene family or …

… for drug metabolism are CES1 and CES2 [1, 2, 6-8]. Interestingly, CESs could serve as both
drugs and drug targets [9… review: Mammalian carboxylesterases: From drug targets to protein …

… Without exceptions, all mammalian species studied express multiple forms of carboxylesterases.
Two … Without exceptions, all mammalian species studied express multiple forms of …

Carboxylesterases (CE) are ubiquitous enzymes responsible for the detoxification of
xenobiotics. Many therapeutically useful drugs are metabolized by these proteins which impacts …

… Gly 143 in the HGGG motif is also highly conserved among all mammalian carboxylesterases
and is essential for carboxylesterase activity. Notably, the active cavity of human CES1 is …

… These are the first structures of a human carboxylesterase, and … could serve as both a drug
and a drug target. Selective hCE1 … proposed for a related mammalian carboxylesterase [25]. …

… Mammalian carboxylesterases hydrolyze a wide range of … Physiological functions of
carboxylesterases in lipid … In this system, mammalian carboxylesterases are grouped into …

… drug, and is bioconverted to the active drug in vivo. Through chemical modification of a drug
to a prodrug, we are able to deliver drugs to the target … drugs is via carboxylesterase (CES) …

… mammals demonstrate different levels of carboxylesterase … of drug and/or hydrolysis products
present within target tissues … the ester function in drug design will significantly reduce and/…