Carboxylesterases (CESs) play major roles in catalyzing the hydrolysis of a wide range of
ester- and amide-containing compounds. CESs dominate both the biotransformation of …

… Owing to their relatively low toxicity to mammals in contrast to organophosphorus insecticides,
… Mammalian carboxylesterases (CES) are important members of the serine hydrolase …

… The Potter laboratory has evaluated these as selective inhibitors of mammalian CEs, and
we have observed essentially no inhibition of recombinant purified enzymes (hiCE, hCE1 and …

… The mammalian carboxylesterases have become enzymes of increasing interest, particularly
in regard to potential activities as cholesteryl ester and/or triacylglyceride hydrolases (…

… List of carboxylesterase genes used in this study from non-mammals. These genes are first
being reported in this study and were identified through genomic searches using Ensembl. …

… processes in both development and adult mammalian biology. This Perspective will provide
… of Notum carboxylesterase activity providing chemical tools for use in drug target validation …

… first structural view of a mammalian carboxylesterase and insights into CPT-11 activation. …
of esterase function and the ability of mammalian carboxylesterases to act on a wide variety of …

… The paper also reviews the major roles for mammalian CES1, CES2 and CES5 family
members, and discusses potential roles for CES5 as a body fluid carboxylesterase and in …

… Overall, this article describes the selective inhibition of mammalian CEs by aromatic
ethane-1,2-diones. Compounds with K i values as low as 30 pM have been observed for the …

… Species-, sex-, and age-dependent urinary excretion of cauxin, a mammalian carboxylesterase.
Comp Biochem Physiol B Biochem Mol Biol 145: 270–277. Miyazaki M, Yamashita T, …