… -MAPK pathway represents … therapy prevents the development of acquired resistance as
well as decreasing cutaneous toxicity secondary to paradoxical activation of the MAPK pathway …

… MAP kinase kinase) occupies a strategic downstream position in this intracellular signaling
cascade catalyzing the phosphorylation of its MAP kinase … of signals into the MAPK pathway. …

… This is the main direction in which therapies based on inhibitory molecules were developed.
… activated MAPK pathway in cancer is one of the most explored therapeutic approaches. …

… revealed common mutations in MAPK/ERK pathway components, such as v‐… MAPK and
other pathways to optimize the treatment of many tumor types. Therapies targeted toward MAPK/…

… The p38 MAP kinase pathway shares many similarities with the other MAP kinase cascades,
… To date, four p38 MAP kinase isoforms have been identified sharing about 60% homology. …

… in the MAPK and PI3K/AKT/mTOR pathways has led to the rational development of targeted
therapies. Combining BRAF and MEK inhibitors to target two steps in the MAPK pathway (…

… and discuss the MAPK pathway inhibiting therapies and major … also the combination therapy
strategies with MAPK inhibitors in … still hold promise as therapeutic approach for melanoma. …

… Areas covered: The biological role of the RAS–MAPK pathway, the … The rationale for targeting
the RAS–MAPK pathway and the … therapeutic approaches would be the best approach to …

… pathway in human cancer, targeting the MAPK pathway has long been considered a promising
strategy for cancer therapy. … of suppressing MAPK signaling by these approaches is still …

… faced targeting the MAPK pathway and why certain therapeutic approaches succeed while
… , therapeutic potential and the drugs available to target each member of the pathway as well …