Compartmentalised MAPK pathways

MD Brown, DB Sacks - Protein-protein interactions as new drug targets, 2008 - Springer
… The mitogen-activated protein kinase (MAPK) pathway provides cells with the means to … of
MAPK signalling, cells can control their responses to the multiple activators of the pathway. In …

The role of Nrf2 and MAPK pathways in PFOS-induced oxidative stress in zebrafish embryos

X Shi, B Zhou - Toxicological Sciences, 2010 - academic.oup.com
… on the MAPK pathway, we also examined the effects of SFN treatment on MAPK gene
expression. … To evaluate the role of MAPK pathways in the regulation of HO-1 responses, we used …

[HTML][HTML] Map kinase signaling pathways and hematologic malignancies

LC Platanias - Blood, 2003 - Elsevier
… Dual roles for Map kinase pathways in the induction of cytokine responses. Regulation of
cytokine production and participation in cytokine-dependent signaling cascades. …

Formation of stress granules inhibits apoptosis by suppressing stress-responsive MAPK pathways

K Arimoto, H Fukuda, S Imajoh-Ohmi, H Saito… - Nature cell …, 2008 - nature.com
… JNK MAPK (SAPK) pathways. A functional relationship between the SG and SAPK responses
… Here, we report that SG formation negatively regulates the SAPK apoptotic response, and …

A Single MAPKKK Regulates the Hog1 MAPK Pathway in the Pathogenic Fungus Candida albicans

J Cheetham, DA Smith, A da Silva Dantas… - Molecular biology of …, 2007 - Am Soc Cell Biol
… Furthermore, the role of the stress-responsive MAPK pathways in mediating core
transcriptional responses to stress is different in C. albicans (Enjalbert et al., 2006), S. cerevisiae (…

Role of MAPK pathways in light chain-induced cytokine production in human proximal tubule cells

S Sengul, C Zwizinski… - American Journal of …, 2003 - journals.physiology.org
… Here, we examined the role of MAPK pathways in these responses using four species of
myeloma LCs (κ 1 , κ 2 , κ 3 , and λ 1 ) previously shown to induce cytokine production by PTCs. …

Targeting MAPK pathway in melanoma therapy

Y Cheng, G Zhang, G Li - Cancer and Metastasis Reviews, 2013 - Springer
… (MAPK) pathway have generated striking clinical response in … , therapies targeting the MAPK
pathway have been proven … specific molecules in MAPK pathway. Although selective BRAF …

Differential regulation and properties of MAPKs

M Raman, W Chen, MH Cobb - Oncogene, 2007 - nature.com
MAPK cascades consist of a … pathway, these enzymes are capable of responding to a
bewildering number of stimuli to produce exquisitely specific cellular outcomes. These responses

IL-17 stimulates inflammatory responses via NF-κB and MAP kinase pathways in human colonic myofibroblasts

K Hata, A Andoh, M Shimada… - American Journal …, 2002 - journals.physiology.org
… p38 MAPKs as early as 15 min after stimulation. These results indicate that MAPK pathways
… Phosphorylation of the MAPKs was actually blocked by MAPK inhibitors in these cells (Fig. …

[HTML][HTML] Serum deprivation-response protein induces apoptosis in hepatocellular carcinoma through ASK1-JNK/p38 MAPK pathways

X Chen, W Ma, Y Yao, Q Zhang, J Li, X Wu, C Mei… - Cell death & …, 2021 - nature.com
… , because it promoted apoptosis by activating ASK1-JNK/p38 MAPK pathways in HCC. … then
leaded to activation of the JNK/P38 MAPK pathways. The finding provided a novel antitumor …