[HTML][HTML] Association of MAPT haplotypes with Alzheimer's disease risk and MAPT brain gene expression levels
…, Alzheimer's Disease Genetics Consortium … - Alzheimer's research & …, 2014 - Springer
… of MAPT haplotypes with … the Alzheimer’s Disease Genetics Consortium (ADGC, n-cases
= 7,762, n-controls = 8,144). We also assessed associations with brain MAPT gene expression …
= 7,762, n-controls = 8,144). We also assessed associations with brain MAPT gene expression …
[HTML][HTML] Regulation of human MAPT gene expression
ML Caillet-Boudin, L Buée, N Sergeant… - Molecular …, 2015 - Springer
… expression/metabolism in many pathologies, the regulation of the expression of the MAPT
gene, … The most commonly studied aspects include MAPT haplotypes and Tau RNA splicing …
gene, … The most commonly studied aspects include MAPT haplotypes and Tau RNA splicing …
CDK5 and MAPT gene expression in Alzheimer's disease brain samples
JT Fukasawa, RW de Labio… - Current Alzheimer …, 2018 - ingentaconnect.com
… Background: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by …
the expression of the MAPT gene and CDK5 (the gene involved in cell cycle regulation) in …
the expression of the MAPT gene and CDK5 (the gene involved in cell cycle regulation) in …
Combined Connectomics, MAPT Gene Expression, and Amyloid Deposition to Explain Regional Tau Deposition in Alzheimer Disease
…, Alzheimer's Disease Neuroimaging Initiative - Annals of …, 2024 - Wiley Online Library
… Based on the whole-brain map, we computed the average MAPT gene expression level
in … the mask onto the MAPT gene expression map to obtain the ROI expression values. …
in … the mask onto the MAPT gene expression map to obtain the ROI expression values. …
Blood MAPT expression and methylation status in Alzheimer's disease
H Mori, Y Yoshino, M Ueno… - Psychiatry and …, 2022 - Wiley Online Library
… for MAPT gene expression or AD pathology. However, AChEIs may alter MAPT mRNA
expression. … We therefore hypothesized that MAPT mRNA expression levels and the methylation …
expression. … We therefore hypothesized that MAPT mRNA expression levels and the methylation …
[HTML][HTML] Alternative promoter usage generates novel shorter MAPT mRNA transcripts in Alzheimer's disease and progressive supranuclear palsy brains
… Our present results showed that like many genes expressed in the brain, MAPT has an
alternative promoter. This promoter is located upstream of exon 1 and is active in brain tissue. …
alternative promoter. This promoter is located upstream of exon 1 and is active in brain tissue. …
MAPT expression and splicing is differentially regulated by brain region: relation to genotype and implication for tauopathies
… disease and possibly Alzheimer's disease, but also due its … regional variation in MAPT
mRNA expression and splicing, … that at the gene-level MAPT mRNA expression and total tau …
mRNA expression and splicing, … that at the gene-level MAPT mRNA expression and total tau …
[HTML][HTML] Gene expression endophenotypes: a novel approach for gene discovery in Alzheimer's disease
N Ertekin-Taner - Molecular neurodegeneration, 2011 - Springer
… characterization of disease risk genes[8, 9]. This review focuses on gene expression levels
… be used to map genetic variants underlying disease risk, heritability or having a measurable …
… be used to map genetic variants underlying disease risk, heritability or having a measurable …
Altered neuronal gene expression in brain regions differentially affected by Alzheimer's disease: a reference data set
WS Liang, T Dunckley, TG Beach… - Physiological …, 2008 - journals.physiology.org
… Heat map of differentially expressed genes in the entorhinal cortex (EC). A heat map for EC
was … corrections applied) genes with the greatest region-specific fold changes. Normalized …
was … corrections applied) genes with the greatest region-specific fold changes. Normalized …
The MAPT gene is differentially methylated in the progressive supranuclear palsy brain
V Huin, V Deramecourt… - … Disorders, 2016 - Wiley Online Library
… tauopathies (35 Alzheimer's disease, 10 corticobasal … MAPT mRNA expression in both of
the brain regions we examined. We present the first report of overexpression of MAPT mRNA in …
the brain regions we examined. We present the first report of overexpression of MAPT mRNA in …
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