[HTML][HTML] Increasing Signal Specificity of the TOL Network of Pseudomonas putida mt-2 by Rewiring the Connectivity of the Master Regulator XylR

A de Las Heras, S Fraile, V de Lorenzo - 2012 - journals.plos.org
… putida mt-2. While XylR, the chief TF of this system, binds this substrate and activates Pu,
the same regulator responds, to a lesser extent, to 3-methylbenzylalcohol and thus also …

Regulating a master regulator: establishing tissue-specific gene expression in skeletal muscle

A Aziz, QC Liu, FJ Dilworth - Epigenetics, 2010 - Taylor & Francis
… coordinately as regulators of a master regulator to mediate … is a master regulator of
skeletal myogenesisCitation1 due to its ability to initiate the myogenic program in myoblasts,Citation2

Functional MT1 and MT2 melatonin receptors in mammals

ML Dubocovich, M Markowska - Endocrine, 2005 - Springer
… Endogenous pineal melatonin is believed to feed back onto the master clock and to
regulate neuronal activity and circadian rhythms through activation of specific MT1 and MT2

Melatonin promotes self-renewal of nestin-positive pancreatic stem cells through activation of the MT2/ERK/SMAD/nestin axis

C Bai, Y Gao, X Zhang, W Yang… - … Cells, Nanomedicine, and …, 2018 - Taylor & Francis
… Melatonin receptors in mammals include 2 high-affinity receptors, MT1 and MT2, which
we tested using IF and RT-PCR. Figure 1(B,E) shows that MT1, MT2 and nestin were co-…

Minireview: Toward the Establishment of a Link between Melatonin and Glucose Homeostasis: Association of Melatonin MT2 Receptor Variants with Type 2 Diabetes

A Karamitri, N Renault, N Clement… - Molecular …, 2013 - academic.oup.com
… In the second part of the minireview, we will discuss the consequences of these MT 2 mutants
on receptor structure and their impact on our understanding of melatonin's role in glucose …

Type 2 diabetes–associated variants of the MT2 melatonin receptor affect distinct modes of signaling

A Karamitri, B Plouffe, A Bonnefond, M Chen… - Science …, 2018 - science.org
… In the hypothalamic suprachiasmatic nuclei, MT 1 and MT 2 regulate the circadian rhythms
of the master clock in mammals, and disruption of central and peripheral circadian rhythms …

The emergence of 2-oxoglutarate as a master regulator metabolite

LF Huergo, R Dixon - Microbiology and Molecular Biology …, 2015 - Am Soc Microbiol
… We then review the novel interplay between the 2-OG and cyclic AMP (cAMP) levels in E. …
of 2-OG as a master regulator in eukaryotes and discuss the major points and challenges in 2-…

MT1 and MT2 Melatonin Receptors: A Therapeutic Perspective

J Liu, SJ Clough, AJ Hutchinson… - Annual review of …, 2016 - annualreviews.org
… receptor antagonist luzindole (MT1/MT2-nonselective) and 4P-PDOT (MT2-selective) varies
… totally blind individuals who are unable to entrain their master body clock to the 24-h light-…

[HTML][HTML] Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability

GG McGill, M Horstmann, HR Widlund, J Du… - Cell, 2002 - cell.com
Kit/SCF signaling and Mitf-dependent transcription are both essential for melanocyte
development and pigmentation. To identify Mitf-dependent Kit transcriptional targets in primary …

Melatonin influences somatostatin secretion from human pancreatic δ‐cells via MT1 and MT2 receptors

J Zibolka, E Mühlbauer, E Peschke - Journal of pineal research, 2015 - Wiley Online Library
MT2‐selective antagonist 4‐P‐PDOT (4‐phenyl‐2‐propionamidotetraline), an involvement
of the MT1 receptor can be assumed. Somatostatin release from the δ‐cells at low glucose …