… Melatonin-dependent activation of MT2 impacts PKC and ERK1/2 complexes. ERK1/2 and
CREB pathways converge onto transcription of clock genes and neurotrophic factors genes (…

… primer set homologous to the bovine MT 2 mRNA sequence, we have cloned and characterized
MT 2 receptors from sheep retina. Key results: The ovine MT 2 receptor presents 96%, …

… expression of adipogenic master regulator PPARγ; (B) the mRNA expression of adipogenic
master regulator C/EBPβ; (C) the mRNA expression of adipogenic master regulator C/EBPα; (…

… Our studies during the past several years have revealed that the ER molecular chaperone
BiP is a master regulator of ER function. It is responsible for maintaining the permeability …

… (CRISPR)‐mediated knockdown of FOXP3 in MT‐2 cells to understand the … MT‐2 cells with
primary human Tregs. We demonstrate that loss of FOXP3 affects the transcriptome of MT‐2 …

… Good examples are the transcription factors Pou5f1 (also known as Oct4), Sox2 and Nanog,
which are considered ‘master regulators’ of stem cell pluripotency with the ability to revert …

… Here, we summarize molecular pathways in which melatonin is considered a master
regulator, with attention to cell death and inflammation mechanisms from basic, translational and …

… MT 1 −/− /MT 2 −/− mice. Our results show that the genetic inactivation of both MT 1 and
MT 2 … receptors, controls the activity of the suprachiasmatic nucleus (SCN) [4], [5], [6], the “master …

… coupled melatonin MT 1 and MT 2 receptors has not yet been well-clarified. Recent
advancements using selective MT 1 / MT 2 receptor ligands and MT 1 /MT 2 receptor knockout mice …

… This review summarizes the recent genomic and genetic analyses of CArG-SRF that support
its role as an ancient, master regulator of the actin cytoskeleton and contractile machinery. …