Functional hierarchy and cooperation of EMT master transcription factors in breast cancer metastasis

JB Addison, MA Voronkova, JH Fugett, CC Lin… - Molecular Cancer …, 2021 - AACR
… These results provide strong evidence that EMT is orchestrated by coordinated expression
of several EMT-TFs and establish ZEB1 as a key master regulator of EMT and metastasis in …

Different susceptibility to the Parkinson's toxin MPTP in mice lacking the redox master regulator Nrf2 or its target gene heme oxygenase-1

NG Innamorato, A Jazwa, AI Rojo, C Garcia… - PloS one, 2010 - journals.plos.org
… We have focused on the role of Nrf2, master regulator of the whole phase II response, and
HO-1 a polemic phase II enzyme that has been speculated to be both neuroprotective and …

Melatonin inhibits granulocyte adhesion to ICAM via MT3/QR2 and MT2 receptors

V Černyšiov, M Mauricas… - International Immunology, 2015 - academic.oup.com
… This study additionally showed that melatonin receptors MT2 and MT3/quinone reductase
2 (QR2) are expressed on granulocytes. Interestingly, melatonin increases the expression of …

Nrf2, the master regulator of anti-oxidative responses

S Vomund, A Schäfer, MJ Parnham, B Brüne… - International journal of …, 2017 - mdpi.com
… As a master regulator of antioxidative responses, the expression of Nrf2 is tightly regulated.
Under healthy conditions, Nrf2 mRNA is constitutively expressed [4] and Nrf2 expression is …

[HTML][HTML] Melatonin MT2 receptor is expressed and potentiates contraction in human airway smooth muscle

H Sasaki, Y Zhang, CW Emala Sr… - American Journal of …, 2021 - journals.physiology.org
… expression of the melatonin MT 2 but not the MT 1 receptor in … MT 2 receptors with either
pharmacological concentrations of melatonin (10–100 µM) or the nonselective MT 1 /MT 2

Melatonin: a new plant hormone and/or a plant master regulator?

MB Arnao, J Hernández-Ruiz - Trends in Plant Science, 2019 - cell.com
… actions also point to it being an important master regulator of redox homeostasis in plants. …
master regulator. Here, we discuss the most recent data in respect to both perspectives. …

Nuclear receptor coactivators: master regulators of human health and disease

S Dasgupta, DM Lonard… - Annual review of …, 2014 - annualreviews.org
… as master regulators of human pathologies (7). Peroxisome proliferator-activated receptor
gamma, coactivator 1 alpha (PGC-1α) is another critical coregulator, which is involved in the …

FurA is the master regulator of iron homeostasis and modulates the expression of tetrapyrrole biosynthesis genes in Anabaena sp. PCC 7120

A González, MT Bes, A Valladares… - Environmental …, 2012 - Wiley Online Library
… In this study, we unravel the role of FurA as the master regulator of iron metabolism analysing
the impact of FurA overexpression and iron availability on the transcriptional modulation of …

[HTML][HTML] Zinc transporter Slc30a1 regulates melanocyte development by interacting with mt2 in zebrafish

Z Xia, X Yang, X Bi, X Tong, J Min, F Wang - European Journal of Cell …, 2022 - Elsevier
… melanoma pathway and the gene mt2, which encodes zinc-binding protein, were significantly
upregulated in the mutants. In addition, the expression of mt2 was specifically increased in …

Stochasticity of TOL plasmid catabolic promoters sets a bimodal expression regime in Pseudomonas putida mt2 exposed to m‐xylene

R Silva‐Rocha, V de Lorenzo - Molecular microbiology, 2012 - Wiley Online Library
The expression dynamics of the catabolic promoters of the TOL plasmid pWW0 has been
examined in single cells of Pseudomonas putida mt2 exposed to m‐xylene. To this end, we …