The IκB kinase complex: master regulator of NF-κB signaling

LA Solt, MJ May - Immunologic research, 2008 - Springer
NF-κB signaling an attractive target for the development of anti-inflammatory and anti-cancer
drugs. A pivotal regulator of all inducible NF-κB … subunit named NF-κB essential modulator (…

NF-κB in monocytes and macrophages–an inflammatory master regulator in multitalented immune cells

M Mussbacher, M Derler, J Basílio… - Frontiers in …, 2023 - frontiersin.org
… of myeloid NF-κB activation and underlined the complexity of this inflammatory master
regulator. This review will provide an overview of the complex roles of NF-κB in macrophage …

NFκB in Photodynamic Therapy: Discrepancies of a Master Regulator

JY Matroule, C Volanti, J Piette - Photochemistry and …, 2006 - Wiley Online Library
… In the present review, we aim to summarize the current knowledge on NFκB status
following photosensitization of cancer cells and endothelial cells. In order to unravel the NFκB

The IκB Kinase Complex and NF-κB Actas Master Regulators of Lipopolysaccharide-Induced Gene Expressionand Control Subordinate Activation ofAP-1

D Krappmann, E Wegener, Y Sunami… - … and cellular biology, 2004 - Am Soc Microbiol
… we demonstrate a master regulatory role of IκB kinase (IKK)/NF-κB signaling for immediate-early
gene induction after LPS engagement in precursor B cells. IKK/NF-κB signaling controls …

The IκB kinase: a master regulator of NF-κB, innate immunity, and epidermal differentiation

M Delhase, M Karin - Cold Spring Harbor Symposia on …, 1999 - symposium.cshlp.org
… There is ample genetic evidence that IKK is the master regulator of NF-κB. Because NF-κB
), IKK should be considered as the master regulator of this highly important and evolutionarily …

Andrographolide: Regulating the master regulator NF-κB

KP Mishra - Indian Journal of Clinical Biochemistry, 2021 - Springer
… of NF-κB with DNA at promoter site. Transcription factor NF-κB is a master regulator of the …
andrographolide, hence andrographolide is rightly termed as regulator of master regulator. …

RIP1's function in NF-κB activation: from master actor to onlooker

MJM Bertrand, P Vandenabeele - Cell Death & Differentiation, 2010 - nature.com
… The de-ubiquitinating enzymes A20 and CYLD have been identified as negative regulators
that edit RIP1 K 63 -polyubiquitin chains, thereby limiting the duration of the NF-κB response. …

Evidence for the involvement of the master transcription factor NF-κB in cancer initiation and progression

YR Puar, MK Shanmugam, L Fan, F Arfuso, G Sethi… - Biomedicines, 2018 - mdpi.com
… of NF-κB activation, the role of NF-κB in tumor promotion and suppression, as well as a few
important pharmacological strategies that have been developed to modulate NF-κB function. …

The regulation of NF-κB subunits by phosphorylation

F Christian, EL Smith, RJ Carmody - Cells, 2016 - mdpi.com
… The NF-κB transcription factor is the master regulator of the inflammatory response and is
essential for the homeostasis of the immune system. NF-κB regulates the transcription of genes …

Extensive cooperation of immune master regulators IRF3 and NFκB in RNA Pol II recruitment and pause release in human innate antiviral transcription

JE Freaney, R Kim, R Mandhana, CM Horvath - Cell reports, 2013 - cell.com
Transcription factors interferon regulatory factor 3 (IRF3) and nuclear factor κB (NFκB) are
activated by external stimuli, including virus infection, to translocate to the nucleus and bind …