… in mechanically compressed cartilage explants. Our objectives were to: (1) quantify the effects
of static and dynamic compression … and matrix associated with tissue compression; and (3) …

… to test the hypothesis that cyclic mechanical compression of cartilage alters the release of …
A range of compressive loads was applied to articular cartilage explants to induce physiologic …

… mechanical forces in vivo and in the cartilage explant model, we hypothesized that mechanical
… response of chondrocytes from intact cartilage to static compression, focusing on a range …

… to determine if injurious mechanical compression of cartilage explants results in changes
at the level of gene transcription that may lead to subsequent degradation of the cartilage. …

… adult bovine articular cartilage explants synthesize proteoglycans … mechanical compression
have utilized cartilage explants (5,22,23,32,56,64,65,69). The physical properties of cartilage …

… These findings indicate that NO production by chondrocytes is influenced by mechanical
compression in vitro and suggest that biomechanical factors may in part regulate NO production …

… of mechanical loading on cartilage metabolism in … cartilage explants to equilibrium compressive
stresses. Rates of proteoglycan synthesis and release were determined for the explants …

… mechanical deformation to full-thickness cartilage explants … fined compression imposed on
mature articular cartilage was … in minutes) reduced mechanical properties, immediate damage …

… After l2 days compression, unloading led to an increase in … The effect of mechanical loading
of cartilage explants on loss … levels of mechanical compression of cartilage explants on the …

… explants, encouraging matrix production and deposition. The addition of static mechanical
compression … factor, suggesting that static compression and growth factors may modulate …