Target identification and mechanism of action in chemical biology and drug discovery
M Schenone, V Dančík, BK Wagner… - … chemical biology, 2013 - nature.com
… Modern chemical biology and drug discovery each seek to identify new small molecules
that potently and selectively modulate the functions of target proteins. Historically, nature has …
that potently and selectively modulate the functions of target proteins. Historically, nature has …
Chemical biology of epothilones
KC Nicolaou, F Roschangar… - Angewandte Chemie …, 1998 - Wiley Online Library
… desire to produce a large epothilone library for chemical biology studies, we sought to
develop a solid phase synthesis of epothilone A, whichÐwe projectedÐwould be amenable to …
develop a solid phase synthesis of epothilone A, whichÐwe projectedÐwould be amenable to …
The chemical biology of S-nitrosothiols
KA Broniowska, N Hogg - Antioxidants & redox signaling, 2012 - liebertpub.com
… biological chemistry of S-nitrosation and to point out where the challenges lie in matching the
known chemical biology of … the mechanisms of the formation of S-nitrosothiols in biological …
known chemical biology of … the mechanisms of the formation of S-nitrosothiols in biological …
Chemistry and chemical biology of taxane anticancer agents
… Herein, we describe our studies on the chemistry and chemical biology of paclitaxel and its
… The following sections will review our studies on the chemistry and chemical biology of the …
… The following sections will review our studies on the chemistry and chemical biology of the …
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Chemical biology of nitric oxide: insights into regulatory, cytotoxic, and cytoprotective mechanisms of nitric oxide
DA Wink, JB Mitchell - Free Radical Biology and Medicine, 1998 - Elsevier
… This report discusses various aspects of the chemical biology of NO relating to biological …
of NO in different biological events. Also, the implications of different chemical reactions of NO …
of NO in different biological events. Also, the implications of different chemical reactions of NO …
DNA-damaging agents in cancer chemotherapy: serendipity and chemical biology
… for their mechanisms of action. This review covers the current DNA-damaging agents
used in the clinic, discusses their limitations, and describes the use of chemical genomics to …
used in the clinic, discusses their limitations, and describes the use of chemical genomics to …
Chemical biology of nitric oxide: regulation and protective and toxic mechanisms
DA Wink, I Hanbauer, MB Grisham, F Laval… - Current topics in cellular …, 1996 - Elsevier
… understanding the chemical biology of NO, which can be defined as the fundamental chemistry
that pertains to specific biological conditions. Consideration of these chemical reactions …
that pertains to specific biological conditions. Consideration of these chemical reactions …
Chemical biology of tetracycline antibiotics
B Zakeri, GD Wright - Biochemistry and Cell Biology, 2008 - cdnsciencepub.com
Chemical biology of tetracycline antibiotics This paper is one of a selection of papers
published in this Special Issue, entitled CSBMCB — Systems and Chemical Biology, and has …
published in this Special Issue, entitled CSBMCB — Systems and Chemical Biology, and has …
The chemical biology of clinically tolerated NMDA receptor antagonists
HSV Chen, SA Lipton - Journal of neurochemistry, 2006 - Wiley Online Library
… memantine action (Chen and Lipton 2005; Yuan et al. 2005; Johnson and Kotermanski
2006). Here, we review the molecular mechanism of memantine's clinically tolerated action and …
2006). Here, we review the molecular mechanism of memantine's clinically tolerated action and …
The chemical biology of nitric oxide: implications in cellular signaling
DD Thomas, LA Ridnour, JS Isenberg… - Free Radical Biology …, 2008 - Elsevier
… chemical and biochemical parameters that shape cellular responses to NO. Herein we discuss
signal transduction and the chemical biology … concept of the chemical biology of NO was …
signal transduction and the chemical biology … concept of the chemical biology of NO was …