… Modern chemical biology and drug discovery each seek to identify new small molecules
that potently and selectively modulate the functions of target proteins. Historically, nature has …

… desire to produce a large epothilone library for chemical biology studies, we sought to
develop a solid phase synthesis of epothilone A, whichÐwe projectedÐwould be amenable to …

… biological chemistry of S-nitrosation and to point out where the challenges lie in matching the
known chemical biology of … the mechanisms of the formation of S-nitrosothiols in biological …

… Herein, we describe our studies on the chemistry and chemical biology of paclitaxel and its
… The following sections will review our studies on the chemistry and chemical biology of the …

… This report discusses various aspects of the chemical biology of NO relating to biological …
of NO in different biological events. Also, the implications of different chemical reactions of NO …

… for their mechanisms of action. This review covers the current DNA-damaging agents
used in the clinic, discusses their limitations, and describes the use of chemical genomics to …

… understanding the chemical biology of NO, which can be defined as the fundamental chemistry
that pertains to specific biological conditions. Consideration of these chemical reactions …

Chemical biology of tetracycline antibiotics This paper is one of a selection of papers
published in this Special Issue, entitled CSBMCB — Systems and Chemical Biology, and has …

… memantine action (Chen and Lipton 2005; Yuan et al. 2005; Johnson and Kotermanski
2006). Here, we review the molecular mechanism of memantine's clinically tolerated action and …

… chemical and biochemical parameters that shape cellular responses to NO. Herein we discuss
signal transduction and the chemical biology … concept of the chemical biology of NO was …